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Authors: Pérez-Martínez, Lara
Wagner, Tina
Luke, Brian
Title: Telomere interacting proteins and TERRA regulation
Online publication date: 31-Oct-2022
Year of first publication: 2022
Language: english
Abstract: Telomere shortening rates inversely correlate with life expectancy and hence it is critical to understand how telomere shortening is regulated. Recently, the telomeric non-coding RNA, TERRA has been implicated in the regulation of replicative senescence. To better understand how TERRA is regulated we employed a proteomics approach to look for potential RNA regulators that associate with telomeric sequences. Based on the results, we have identified proteins that may regulate TERRA in both a positive and negative manner, depending on the state of the telomere. In this mini-review, we discuss and speculate about these data to expand our understanding of TERRA and telomere interactors with respect to telomere shortening dynamics.
DDC: 610 Medizin
610 Medical sciences
Institution: Johannes Gutenberg-Universität Mainz
Department: FB 04 Medizin
Place: Mainz
Version: Published version
Publication type: Zeitschriftenaufsatz
Document type specification: Review
License: CC BY
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Journal: Frontiers in genetics
Pages or article number: 872636
Publisher: Frontiers Media
Publisher place: Lausanne
Issue date: 2022
ISSN: 1664-8021
Publisher DOI: 10.3389/fgene.2022.872636
Appears in collections:DFG-491381577-G

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