Authors:	Pérez-Martínez, Lara Wagner, Tina Luke, Brian
Title:	Telomere interacting proteins and TERRA regulation
Online publication date:	31-Oct-2022
Year of first publication:	2022
Language:	english
Abstract:	Telomere shortening rates inversely correlate with life expectancy and hence it is critical to understand how telomere shortening is regulated. Recently, the telomeric non-coding RNA, TERRA has been implicated in the regulation of replicative senescence. To better understand how TERRA is regulated we employed a proteomics approach to look for potential RNA regulators that associate with telomeric sequences. Based on the results, we have identified proteins that may regulate TERRA in both a positive and negative manner, depending on the state of the telomere. In this mini-review, we discuss and speculate about these data to expand our understanding of TERRA and telomere interactors with respect to telomere shortening dynamics.
DDC:	610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-8195
Version:	Published version
Publication type:	Zeitschriftenaufsatz
Document type specification:	Review
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/4.0/
Journal:	Frontiers in genetics 13
Pages or article number:	872636
Publisher:	Frontiers Media
Publisher place:	Lausanne
Issue date:	2022
ISSN:	1664-8021
Publisher DOI:	10.3389/fgene.2022.872636
Appears in collections:	DFG-491381577-G