Telomere interacting proteins and TERRA regulation

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dc.contributor.authorPérez-Martínez, Lara
dc.contributor.authorWagner, Tina
dc.contributor.authorLuke, Brian
dc.date.accessioned2022-10-31T08:59:29Z
dc.date.available2022-10-31T08:59:29Z
dc.date.issued2022
dc.description.abstractTelomere shortening rates inversely correlate with life expectancy and hence it is critical to understand how telomere shortening is regulated. Recently, the telomeric non-coding RNA, TERRA has been implicated in the regulation of replicative senescence. To better understand how TERRA is regulated we employed a proteomics approach to look for potential RNA regulators that associate with telomeric sequences. Based on the results, we have identified proteins that may regulate TERRA in both a positive and negative manner, depending on the state of the telomere. In this mini-review, we discuss and speculate about these data to expand our understanding of TERRA and telomere interactors with respect to telomere shortening dynamics.en_GB
dc.description.sponsorshipGefördert durch die Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 491381577de
dc.identifier.doihttp://doi.org/10.25358/openscience-8195
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/8210
dc.language.isoengde
dc.rightsCC-BY-4.0*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.ddc610 Medizinde_DE
dc.subject.ddc610 Medical sciencesen_GB
dc.titleTelomere interacting proteins and TERRA regulationen_GB
dc.typeZeitschriftenaufsatzde
jgu.journal.titleFrontiers in geneticsde
jgu.journal.volume13de
jgu.organisation.departmentFB 04 Medizinde
jgu.organisation.nameJohannes Gutenberg-Universität Mainz
jgu.organisation.number2700
jgu.organisation.placeMainz
jgu.organisation.rorhttps://ror.org/023b0x485
jgu.pages.alternative872636de
jgu.publisher.doi10.3389/fgene.2022.872636de
jgu.publisher.issn1664-8021de
jgu.publisher.nameFrontiers Mediade
jgu.publisher.placeLausannede
jgu.publisher.year2022
jgu.rights.accessrightsopenAccess
jgu.subject.ddccode610de
jgu.subject.dfgNaturwissenschaftende
jgu.type.contenttypeReviewde
jgu.type.dinitypeArticleen_GB
jgu.type.resourceTextde
jgu.type.versionPublished versionde

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