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Authors: Baeken, Marius W.
Behl, Christian
Title: On the origin of BAG(3) and its consequences for an expansion of BAG3's role in protein homeostasis
Online publication date: 12-Sep-2022
Year of first publication: 2022
Language: english
Abstract: The B-cell CLL 2-associated athanogene (BAG) protein family in general and BAG3, in particular, are pivotal elements of cellular protein homeostasis, with BAG3 playing a major role in macroautophagy. In particular, in the contexts of senescence and degeneration, BAG3 has exhibited an essential role often related to its capabilities to organize and remove aggregated proteins. Exciting studies in different species ranging from human, murine, zebrafish, and plant samples have delivered vital insights into BAG3s' (and other BAG proteins') functions and their regulations. However, so far no studies have addressed neither BAG3's evolution nor its phylogenetic position in the BAG family.
DDC: 610 Medizin
610 Medical sciences
Institution: Johannes Gutenberg-Universität Mainz
Department: FB 04 Medizin
Place: Mainz
Version: Published version
Publication type: Zeitschriftenaufsatz
License: CC BY-NC
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Journal: Journal of cellular biochemistry
Pages or article number: 102
Special Issue: The co-chaperone BAG3: Orchestrator of the cellular task force in response to stress
Publisher: Wiley-Liss
Publisher place: New York, NY
Issue date: 2022
ISSN: 1097-4644
Publisher DOI: 10.1002/jcb.29925
Appears in collections:JGU-Publikationen

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