On the origin of BAG(3) and its consequences for an expansion of BAG3's role in protein homeostasis
| dc.contributor.author | Baeken, Marius W. | |
| dc.contributor.author | Behl, Christian | |
| dc.date.accessioned | 2022-09-12T09:36:28Z | |
| dc.date.available | 2022-09-12T09:36:28Z | |
| dc.date.issued | 2022 | |
| dc.description.abstract | The B-cell CLL 2-associated athanogene (BAG) protein family in general and BAG3, in particular, are pivotal elements of cellular protein homeostasis, with BAG3 playing a major role in macroautophagy. In particular, in the contexts of senescence and degeneration, BAG3 has exhibited an essential role often related to its capabilities to organize and remove aggregated proteins. Exciting studies in different species ranging from human, murine, zebrafish, and plant samples have delivered vital insights into BAG3s' (and other BAG proteins') functions and their regulations. However, so far no studies have addressed neither BAG3's evolution nor its phylogenetic position in the BAG family. | en_GB |
| dc.identifier.doi | http://doi.org/10.25358/openscience-7718 | |
| dc.identifier.uri | https://openscience.ub.uni-mainz.de/handle/20.500.12030/7733 | |
| dc.language.iso | eng | de |
| dc.rights | CC-BY-NC-4.0 | * |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | * |
| dc.subject.ddc | 610 Medizin | de_DE |
| dc.subject.ddc | 610 Medical sciences | en_GB |
| dc.title | On the origin of BAG(3) and its consequences for an expansion of BAG3's role in protein homeostasis | en_GB |
| dc.type | Zeitschriftenaufsatz | de |
| jgu.journal.issue | 1 | de |
| jgu.journal.title | Journal of cellular biochemistry | de |
| jgu.journal.volume | 123 | de |
| jgu.organisation.department | FB 04 Medizin | de |
| jgu.organisation.name | Johannes Gutenberg-Universität Mainz | |
| jgu.organisation.number | 2700 | |
| jgu.organisation.place | Mainz | |
| jgu.organisation.ror | https://ror.org/023b0x485 | |
| jgu.pages.alternative | Special Issue: The co-chaperone BAG3: Orchestrator of the cellular task force in response to stress | de |
| jgu.pages.end | 114 | de |
| jgu.pages.start | 102 | de |
| jgu.publisher.doi | 10.1002/jcb.29925 | de |
| jgu.publisher.issn | 1097-4644 | de |
| jgu.publisher.name | Wiley-Liss | de |
| jgu.publisher.place | New York, NY | de |
| jgu.publisher.year | 2022 | |
| jgu.rights.accessrights | openAccess | |
| jgu.subject.ddccode | 610 | de |
| jgu.type.dinitype | Article | en_GB |
| jgu.type.resource | Text | de |
| jgu.type.version | Published version | de |