Please use this identifier to cite or link to this item:
Authors: Zimmer, Sebastian
Goldust, Mohamad
Bhargava, Shashank
Wegner, Joanna
Grabbe, Stephan
Staubach-Renz, Petra
Title: Combination therapy of recalcitrant severe psoriasis with psoriatic arthritis, diabetes nephropathy, and liver cirrhosis
Online publication date: 7-Sep-2022
Year of first publication: 2022
Language: english
Abstract: Objective: Treatment of recalcitrant moderate-to-severe psoriasis can be challenging. Combination therapy of biologics and immunosuppressive agents can be a new strat-egy for treating therapy- resistant cases with comorbidities, where many systemic medications are contraindicated.Case presentation: We report a case of a 62-year-old diabetic man with a 30-year history of severe plaque psoriasis and psoriatic arthritis with cirrhosis and diabetic nephropathy that was treated successfully in combination with apremilast and etaner-cept after multiple previous unsuccessful treatment attempts.Conclusion: There are no data supporting the combination of apremilast and etaner-cept in the management of recalcitrant cases of moderate-to-severe psoriasis and multiple comorbidities including psoriatic arthritis, diabetic nephropathy, and cirrho-sis. In patients who do not respond to multiple approaches for the treatment of pso-riasis, combination therapy with biologic agents and new systemic medications may lead to dramatic disease control.
DDC: 610 Medizin
610 Medical sciences
Institution: Johannes Gutenberg-Universität Mainz
Department: FB 04 Medizin
Place: Mainz
Version: Published version
Publication type: Zeitschriftenaufsatz
License: CC BY-NC
Information on rights of use:
Journal: Journal of cosmetic dermatology
Pages or article number: 2226
Publisher: Wiley-Blackwell
Publisher place: Oxford
Issue date: 2022
ISSN: 1473-2165
Publisher DOI: 10.1111/jocd.14367
Appears in collections:JGU-Publikationen

Files in This Item:
  File Description SizeFormat
combination_therapy_of_recalc-20220907114200861.pdf165.65 kBAdobe PDFView/Open