Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-7697
Authors: | Zimmer, Sebastian Goldust, Mohamad Bhargava, Shashank Wegner, Joanna Grabbe, Stephan Staubach-Renz, Petra |
Title: | Combination therapy of recalcitrant severe psoriasis with psoriatic arthritis, diabetes nephropathy, and liver cirrhosis |
Online publication date: | 7-Sep-2022 |
Year of first publication: | 2022 |
Language: | english |
Abstract: | Objective: Treatment of recalcitrant moderate-to-severe psoriasis can be challenging. Combination therapy of biologics and immunosuppressive agents can be a new strat-egy for treating therapy- resistant cases with comorbidities, where many systemic medications are contraindicated.Case presentation: We report a case of a 62-year-old diabetic man with a 30-year history of severe plaque psoriasis and psoriatic arthritis with cirrhosis and diabetic nephropathy that was treated successfully in combination with apremilast and etaner-cept after multiple previous unsuccessful treatment attempts.Conclusion: There are no data supporting the combination of apremilast and etaner-cept in the management of recalcitrant cases of moderate-to-severe psoriasis and multiple comorbidities including psoriatic arthritis, diabetic nephropathy, and cirrho-sis. In patients who do not respond to multiple approaches for the treatment of pso-riasis, combination therapy with biologic agents and new systemic medications may lead to dramatic disease control. |
DDC: | 610 Medizin 610 Medical sciences |
Institution: | Johannes Gutenberg-Universität Mainz |
Department: | FB 04 Medizin |
Place: | Mainz |
ROR: | https://ror.org/023b0x485 |
DOI: | http://doi.org/10.25358/openscience-7697 |
Version: | Published version |
Publication type: | Zeitschriftenaufsatz |
License: | CC BY-NC |
Information on rights of use: | https://creativecommons.org/licenses/by-nc/4.0/ |
Journal: | Journal of cosmetic dermatology 21 5 |
Pages or article number: | 2226 2228 |
Publisher: | Wiley-Blackwell |
Publisher place: | Oxford |
Issue date: | 2022 |
ISSN: | 1473-2165 |
Publisher DOI: | 10.1111/jocd.14367 |
Appears in collections: | JGU-Publikationen |
Files in This Item:
File | Description | Size | Format | ||
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combination_therapy_of_recalc-20220907114200861.pdf | 165.65 kB | Adobe PDF | View/Open |