Combination therapy of recalcitrant severe psoriasis with psoriatic arthritis, diabetes nephropathy, and liver cirrhosis
| dc.contributor.author | Zimmer, Sebastian | |
| dc.contributor.author | Goldust, Mohamad | |
| dc.contributor.author | Bhargava, Shashank | |
| dc.contributor.author | Wegner, Joanna | |
| dc.contributor.author | Grabbe, Stephan | |
| dc.contributor.author | Staubach-Renz, Petra | |
| dc.date.accessioned | 2022-09-07T09:41:07Z | |
| dc.date.available | 2022-09-07T09:41:07Z | |
| dc.date.issued | 2022 | |
| dc.description.abstract | Objective: Treatment of recalcitrant moderate-to-severe psoriasis can be challenging. Combination therapy of biologics and immunosuppressive agents can be a new strat-egy for treating therapy- resistant cases with comorbidities, where many systemic medications are contraindicated.Case presentation: We report a case of a 62-year-old diabetic man with a 30-year history of severe plaque psoriasis and psoriatic arthritis with cirrhosis and diabetic nephropathy that was treated successfully in combination with apremilast and etaner-cept after multiple previous unsuccessful treatment attempts.Conclusion: There are no data supporting the combination of apremilast and etaner-cept in the management of recalcitrant cases of moderate-to-severe psoriasis and multiple comorbidities including psoriatic arthritis, diabetic nephropathy, and cirrho-sis. In patients who do not respond to multiple approaches for the treatment of pso-riasis, combination therapy with biologic agents and new systemic medications may lead to dramatic disease control. | en_GB |
| dc.identifier.doi | http://doi.org/10.25358/openscience-7697 | |
| dc.identifier.uri | https://openscience.ub.uni-mainz.de/handle/20.500.12030/7712 | |
| dc.language.iso | eng | de |
| dc.rights | CC-BY-NC-4.0 | * |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | * |
| dc.subject.ddc | 610 Medizin | de_DE |
| dc.subject.ddc | 610 Medical sciences | en_GB |
| dc.title | Combination therapy of recalcitrant severe psoriasis with psoriatic arthritis, diabetes nephropathy, and liver cirrhosis | en_GB |
| dc.type | Zeitschriftenaufsatz | de |
| jgu.journal.issue | 5 | de |
| jgu.journal.title | Journal of cosmetic dermatology | de |
| jgu.journal.volume | 21 | de |
| jgu.organisation.department | FB 04 Medizin | de |
| jgu.organisation.name | Johannes Gutenberg-Universität Mainz | |
| jgu.organisation.number | 2700 | |
| jgu.organisation.place | Mainz | |
| jgu.organisation.ror | https://ror.org/023b0x485 | |
| jgu.pages.end | 2228 | de |
| jgu.pages.start | 2226 | de |
| jgu.publisher.doi | 10.1111/jocd.14367 | de |
| jgu.publisher.issn | 1473-2165 | de |
| jgu.publisher.name | Wiley-Blackwell | de |
| jgu.publisher.place | Oxford | de |
| jgu.publisher.year | 2022 | |
| jgu.rights.accessrights | openAccess | |
| jgu.subject.ddccode | 610 | de |
| jgu.type.dinitype | Article | en_GB |
| jgu.type.resource | Text | de |
| jgu.type.version | Published version | de |