Authors:	Storck, Steffen E. Kurtyka, Magdalena Pietrzik, Claus U.
Title:	Brain endothelial LRP1 maintains blood-brain barrier integrity
Online publication date:	6-Jul-2022
Year of first publication:	2021
Language:	english
Abstract:	The entry of blood-borne molecules into the brain is restricted by the blood–brain barrier (BBB). Various physical, transport and immune properties tightly regulate molecule movement between the blood and the brain to maintain brain homeostasis. A recent study utilizing a pan-endothelial, constitutive Tie2-Cre showed that paracellular passage of blood proteins into the brain is governed by endocytic and cell signaling protein low-density lipoprotein receptor–related protein 1 (LRP1). Taking advantage of conditional Slco1c1-CreERT2 specific to CNS endothelial cells and choroid plexus epithelial cells we now supplement previous results and show that brain endothelial Lrp1 ablation results in protease-mediated tight junction degradation, P-glycoprotein (P-gp) reduction and a loss of BBB integrity.
DDC:	610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-7308
Version:	Published version
Publication type:	Zeitschriftenaufsatz
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/4.0/
Journal:	Fluids and barriers of the CNS 18
Pages or article number:	27
Publisher:	BioMed Central
Publisher place:	London
Issue date:	2021
ISSN:	2045-8118
Publisher DOI:	10.1186/s12987-021-00260-5
Appears in collections:	JGU-Publikationen