Brain endothelial LRP1 maintains blood-brain barrier integrity

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dc.contributor.authorStorck, Steffen E.
dc.contributor.authorKurtyka, Magdalena
dc.contributor.authorPietrzik, Claus U.
dc.date.accessioned2022-07-06T08:32:36Z
dc.date.available2022-07-06T08:32:36Z
dc.date.issued2021
dc.description.abstractThe entry of blood-borne molecules into the brain is restricted by the blood–brain barrier (BBB). Various physical, transport and immune properties tightly regulate molecule movement between the blood and the brain to maintain brain homeostasis. A recent study utilizing a pan-endothelial, constitutive Tie2-Cre showed that paracellular passage of blood proteins into the brain is governed by endocytic and cell signaling protein low-density lipoprotein receptor–related protein 1 (LRP1). Taking advantage of conditional Slco1c1-CreERT2 specific to CNS endothelial cells and choroid plexus epithelial cells we now supplement previous results and show that brain endothelial Lrp1 ablation results in protease-mediated tight junction degradation, P-glycoprotein (P-gp) reduction and a loss of BBB integrity.en_GB
dc.identifier.doihttp://doi.org/10.25358/openscience-7308
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/7322
dc.language.isoengde
dc.rightsCC-BY-4.0*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.ddc610 Medizinde_DE
dc.subject.ddc610 Medical sciencesen_GB
dc.titleBrain endothelial LRP1 maintains blood-brain barrier integrityen_GB
dc.typeZeitschriftenaufsatzde
jgu.journal.titleFluids and barriers of the CNSde
jgu.journal.volume18de
jgu.organisation.departmentFB 04 Medizinde
jgu.organisation.nameJohannes Gutenberg-Universität Mainz
jgu.organisation.number2700
jgu.organisation.placeMainz
jgu.organisation.rorhttps://ror.org/023b0x485
jgu.pages.alternative27de
jgu.publisher.doi10.1186/s12987-021-00260-5de
jgu.publisher.issn2045-8118de
jgu.publisher.nameBioMed Centralde
jgu.publisher.placeLondonde
jgu.publisher.year2021
jgu.rights.accessrightsopenAccess
jgu.subject.ddccode610de
jgu.type.dinitypeArticleen_GB
jgu.type.resourceTextde
jgu.type.versionPublished versionde

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