Gutenberg Open Science

The Open Science Repository of Johannes Gutenberg University Mainz.

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DatensammlungAccess status: Open Access ,
Raw data for "Soil formation and weathering over the past 60 kyr reconstructed using lithium isotopes from Maar records"
(2026) Pogge von Strandmann, Philip; Johannes Gutenberg-Universität Mainz
Chemical weathering of silicate rocks is a fundamental control on the carbon cycle, although on timescales shorter than a few tens of kyr, transient carbon storage becomes more important. However, weathering can still act as an amplifier or inhibitor of the carbon cycle on these timescales. Further, weathering produces soils, a storage reservoir of carbon, although the rate at which soils can be produced is likely highly variable, and remains uncertain. Here, we use lithium isotopes in laminated maar sediments from western Germany to examine weathering and soil formation rates, principally across the rapid warming transitions of Greenland Interstadials (GI), also known as Dansgaard Oeschger (D/O) events, and rapid cooling of Greenland Stadials (GS). Our principal finding is that Li isotope ratios are higher during cooler periods, both on glacial-interglacial and GI-GS event scales. Thus, 7Li values average -2.5 ± 1.6‰ during GI events, and -1.5 ± 1.5‰ in the intervening colder stadial events. Based on the evolution of Li isotopes with weathering, this suggests that there was more soil formation relative to primary mineral dissolution during cooler compared to warmer events. That is not to say that weathering rates were higher, but that clay formation was amplified relative to a given weathering rate when it was cooler, due to the combination of lower erosion rates, thermodynamically favoured conditions for clay formation, and enhanced water-rock contact times, promoting secondary mineral formation. Overall, the data show that soil formation responds even through rapid (~100 years) climate change events.
ZeitschriftenaufsatzAccess status: Open Access ,
Parallel synthesis of 5′-amino-5′-deoxy-adenosine derivatives for focused chemical space exploration and their application as methyltransferase inhibitors
(2025) Hoba, Sabrina N.; Schwickert, Marvin; Kammerer, Luis; Sabin, Mark; Weldert, Annabelle C.; Nidoieva, Zarina; Meidner, J. Laurenz; Barthels, Fabian; Schirmeister, Tanja; Kersten, Christian
Parallel syntheses and their throughput capabilities are powerful tools for the rapid generation of molecule libraries, making them highly beneficial for accelerating hit identification in early-stage drug discovery. Utilizing chemical spaces and virtual libraries enhances time and cost efficiency, enabling the faster exploitation of chemically diverse compounds. In this study, a parallel synthesis method for rapidly generating a 5′-amino-5′-deoxy adenosine-based amide and sulfonamide library of 42 compounds is described with high yields and purity, which is economical and ecological due to the reduced requirements for extensive purification. Methyltransferases recently emerged as promising drug targets. The adenosine-derived library was screened using a fluorescence polarization (FP) assay against model enzymes human DNMT2 and METTL3/14, and SARS-CoV-2 nsp14/10, resulting in the identification of three compounds binding with nanomolar affinity to nsp14/10 and three compounds binding METTL3/14 with low micromolar affinity. To demonstrate the accessibility of a broad variety of adenosine derivatives, a focused virtual chemical space of 25 241 5′-amino-5′-deoxy adenosine amides and sulfonamides, which are accessible via the described synthetic procedure, was generated. This chemical space was further investigated for potential biological applications through virtual screening against nsp14/10 which led to the identification of four additional ligands with low micromolar affinities.
ZeitschriftenaufsatzAccess status: Open Access ,
Chirality without compromise: identical spin crossover behavior between the racemate and the enantiopure Fe(ii) complexes
(2025) Becker, Jens-Georg; Sundaresan, Sriram; Carrella, Luca. M.; Rentschler, Eva
The influence of chirality on the packing of solids, and consequently on the magnetic behavior of spin crossover (SCO) materials, is well documented. Here, we present an exceptional case involving three iron(II) complexes [Fe(LNaph-ODA-(X)-Al)(NCBH3)2]·0.5 CH3CN (X = racemic (C1), R (C2), and S (C3)), based on a new 1,3,4-oxadiazole ligand (LNaph-ODA-(X)-Al) with distinct stereocenters. These complexes have isostructural crystal lattices and identical incomplete thermal spin transitions with T1/2 ≈ 150 K, but unexpectedly, single-crystal X-ray diffraction reveals that the presence and configuration of the stereocenters do not quantifiably impact the solid-state structure or the spin crossover properties.