Gutenberg Open Science

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ZeitschriftenaufsatzAccess status: Open Access ,
AI in dental radiology - improving the efficiency of reporting with ChatGPT : comparative study
(2024) Stephan, Daniel; Bertsch, Annika; Burwinkel, Matthias; Vinayahalingam, Shankeeth; Al-Nawas, Bilal; Kämmerer, Peer W.; Thiem, Daniel G. E.
Background: Structured and standardized documentation is critical for accurately recording diagnostic findings, treatment plans, and patient progress in health care. Manual documentation can be labor-intensive and error-prone, especially under time constraints, prompting interest in the potential of artificial intelligence (AI) to automate and optimize these processes, particularly in medical documentation. Objective: This study aimed to assess the effectiveness of ChatGPT (OpenAI) in generating radiology reports from dental panoramic radiographs, comparing the performance of AI-generated reports with those manually created by dental students. Methods: A total of 100 dental students were tasked with analyzing panoramic radiographs and generating radiology reports manually or assisted by ChatGPT using a standardized prompt derived from a diagnostic checklist. Results: Reports generated by ChatGPT showed a high degree of textual similarity to reference reports; however, they often lacked critical diagnostic information typically included in reports authored by students. Despite this, the AI-generated reports were consistent in being error-free and matched the readability of student-generated reports. Conclusions: The findings from this study suggest that ChatGPT has considerable potential for generating radiology reports, although it currently faces challenges in accuracy and reliability. This underscores the need for further refinement in the AI’s prompt design and the development of robust validation mechanisms to enhance its use in clinical settings.
ZeitschriftenaufsatzAccess status: Open Access ,
Influence of distraction factors on performance in laparoscopic surgery in immersive virtual reality : study protocol of a cross-over trial in medical students and residents—DisLapVR
(2024) Hanke, Laura; Schulte, Richard; Boedecker, Christian; Huettl, Florentine; Saalfeld, Patrick; Chheang, Vuthea; Wessels, Marlene; Castell, Christoph von; Hecht, Heiko; Hansen, Christian; Lang, Hauke; Huber, Tobias
Background: Working in an operating room (OR) is physically and mentally challenging: the operation itself demands the surgeon's full attention, while time and cost efficiency constraints, daily planning, and emergency care interfere with the procedure. Thus, multitasking becomes an integral surgical competence. This study aims to examine the effect of disruptions during surgery in a highly immersive virtual reality (IVR) operation environment combined with a virtual reality (VR) laparoscopy simulator. Objective: This study aims to identify distractions in the OR and their importance in the clinical setting. Methods: An IVR environment was created using a high-resolution, stereoscopic 360° video of the OR. Different distractions were identified, classified as auditory, visual, or audio-visual, and recorded accordingly. The surrounding was combined with a VR laparoscopic simulator. Participants—medical students and surgical residents—received proficiency-based training in basic laparoscopic skills and were blinded to the aim of the experiment. Following a cross-over design, each participant received a unique order of virtual distraction factors while performing tasks on the laparoscopic simulator. During the experiment, subjective passing of time, stress, heart rate, and visually induced motion sickness are recorded. After the experiment, validated questionnaires for usability, immersion, and stress were completed, as well as subjective evaluation of the distractions. The questionnaires used included the system usability scale, Self-Assessment Manikin score, National Aeronautics and Space Administration Task Load Index, and the immersion rating scale as described by Nichols. Performance in the laparoscopic tasks in relation to distractions will be evaluated by the Wilcoxon test and ANOVA for continuous variables. Subgroup analyses in regard to age, gender, and expertise (medical students vs surgical residents) are planned. Results: The described trial started in August 2022 and is ongoing. By July 2024, a total of 30 medical students and 9 surgeons have completed the study. Conclusions: We present a study protocol aiming to identify the impact of different disruptions in OR during laparoscopic training in IVR. Hence, it may lead to an improved awareness of distractions and facilitate accommodations toward an improved work environment. Prior research leads to the hypothesis that the performance of a more experienced surgeon is less impacted by distractions than the performance of inexperienced surgeons and medical students. Furthermore, we investigate which type of distraction has the largest impact on performance. With this knowledge, specific multitasking training can be devised, which may be particularly useful in medical education, for which VR might play a leading role. Additionally, workplace surroundings in the OR can be optimized with this knowledge.
ZeitschriftenaufsatzAccess status: Open Access ,
Effects of cisplatin on the radiation response and DNA damage markers in peripheral blood lymphocytes ex vivo
(2025) Zahnreich, Sebastian; Bhatti, Aisha; Ahmad, Barea; Drabke, Sophia; Kaufmann, Justus; Schmidberger, Heinz
Platinum-based radiochemotherapy is associated with hematologic side effects, impacting patient outcomes. However, the clinical mechanisms of cisplatin and its interaction with ionizing radiation (IR), including in biodosimetry for radiotherapy, have not yet been fully clarified. For this purpose, healthy donors’ peripheral blood lymphocytes (PBLs) were pretreated with cisplatin in a pulse (1–4 h) or continuous (24 h) regimen followed by X-rays. DNA damage was assessed as DNA double-strand breaks using repair foci of γH2AX and 53BP1 after 0.5 h and 24 h in G1 PBLs and a proliferation-based cytokinesis-block micronucleus assay. Additionally, cell death and proliferation activity were measured. Unlike a 1 h pulse, a 24 h cisplatin pretreatment caused a concentration-dependent increase in cisplatin-induced foci while decreasing IR-induced foci, especially 24 h after irradiation. This was accompanied by increased apoptosis, with cisplatin and IR having additive effects. Both genotoxins alone caused a dose-dependent increase in micronuclei, while cisplatin significantly reduced binuclear cells, especially after the 24 h treatment, leading to lower micronuclei frequencies post-irradiation. Our results show that prolonged cisplatin exposure, even at low concentrations, impacts the vitality and division activity of PBLs, with significantly stronger effects post-irradiation. This has major implications and must be considered for the detection of DNA damage-associated biomarkers in PBLs used in clinical prediction or biodosimetry during radiotherapy.