Authors:	Aschauer, Dominik F. Eppler, Jens-Bastian Ewig, Luke Chambers, Anna R. Pokorny, Christoph Kaschube, Matthias Rumpel, Simon
Title:	Learning-induced biases in the ongoing dynamics of sensory representations predict stimulus generalization
Online publication date:	20-Dec-2022
Year of first publication:	2022
Language:	english
Abstract:	Sensory stimuli have long been thought to be represented in the brain as activity patterns of specific neuronal assemblies. However, we still know relatively little about the long-term dynamics of sensory representations. Using chronic in vivo calcium imaging in the mouse auditory cortex, we find that sensory representations undergo continuous recombination, even under behaviorally stable conditions. Auditory cued fear conditioning introduces a bias into these ongoing dynamics, resulting in a long-lasting increase in the number of stimuli activating the same subset of neurons. This plasticity is specific for stimuli sharing representational similarity to the conditioned sound prior to conditioning and predicts behaviorally observed stimulus generalization. Our findings demonstrate that learning-induced plasticity leading to a representational linkage between the conditioned stimulus and non-conditioned stimuli weaves into ongoing dynamics of the brain rather than acting on an otherwise static substrate.
DDC:	570 Biowissenschaften 570 Life sciences 610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-6985
Version:	Published version
Publication type:	Zeitschriftenaufsatz
Document type specification:	Scientific article
License:	CC BY-NC-ND
Information on rights of use:	https://creativecommons.org/licenses/by-nc-nd/4.0/
Journal:	Cell reports 38 6
Pages or article number:	110340
Publisher:	Cell Press
Publisher place:	Maryland Heights, MO
Issue date:	2022
ISSN:	2211-1247
Publisher URL:	https://doi.org/10.1016/j.celrep.2022.110340
Publisher DOI:	10.1016/j.celrep.2022.110340
Appears in collections:	DFG-491381577-G