Gutenberg Open Science: Learning-induced biases in the ongoing dynamics of sensory representations predict stimulus generalization

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-6985

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DC Field	Value	Language
dc.contributor.author	Aschauer, Dominik F.	-
dc.contributor.author	Eppler, Jens-Bastian	-
dc.contributor.author	Ewig, Luke	-
dc.contributor.author	Chambers, Anna R.	-
dc.contributor.author	Pokorny, Christoph	-
dc.contributor.author	Kaschube, Matthias	-
dc.contributor.author	Rumpel, Simon	-
dc.date.accessioned	2022-12-20T10:43:53Z	-
dc.date.available	2022-12-20T10:43:53Z	-
dc.date.issued	2022	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/6997	-
dc.description.abstract	Sensory stimuli have long been thought to be represented in the brain as activity patterns of specific neuronal assemblies. However, we still know relatively little about the long-term dynamics of sensory representations. Using chronic in vivo calcium imaging in the mouse auditory cortex, we find that sensory representations undergo continuous recombination, even under behaviorally stable conditions. Auditory cued fear conditioning introduces a bias into these ongoing dynamics, resulting in a long-lasting increase in the number of stimuli activating the same subset of neurons. This plasticity is specific for stimuli sharing representational similarity to the conditioned sound prior to conditioning and predicts behaviorally observed stimulus generalization. Our findings demonstrate that learning-induced plasticity leading to a representational linkage between the conditioned stimulus and non-conditioned stimuli weaves into ongoing dynamics of the brain rather than acting on an otherwise static substrate.	en_GB
dc.description.sponsorship	Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 491381577	de
dc.language.iso	eng	de
dc.rights	CC BY-NC-ND	*
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject.ddc	570 Biowissenschaften	de_DE
dc.subject.ddc	570 Life sciences	en_GB
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Learning-induced biases in the ongoing dynamics of sensory representations predict stimulus generalization	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-6985	-
jgu.type.contenttype	Scientific article	de
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Cell reports	de
jgu.journal.volume	38	de
jgu.journal.issue	6	de
jgu.pages.alternative	110340	de
jgu.publisher.year	2022	-
jgu.publisher.name	Cell Press	de
jgu.publisher.place	Maryland Heights, MO	de
jgu.publisher.uri	https://doi.org/10.1016/j.celrep.2022.110340	de
jgu.publisher.issn	2211-1247	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	570	de
jgu.subject.ddccode	610	de
jgu.publisher.doi	10.1016/j.celrep.2022.110340	de
jgu.organisation.ror	https://ror.org/023b0x485	-
jgu.subject.dfg	Naturwissenschaften	de
Appears in collections:	DFG-491381577-G

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