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Authors: Duman, Mert
Martinez-Moreno, Margot
Jacob, Claire
Tapinos, Nikos
Title: Functions of histone modifications and histone modifiers in Schwann cells
Online publication date: 6-Aug-2021
Language: english
Abstract: Schwann cells (SCs) are the main glial cells present in the peripheral nervous system (PNS). Their primary functions are to insulate peripheral axons to protect them from the environment and to enable fast conduction of electric signals along big caliber axons by enwrapping them in a thick myelin sheath rich in lipids. In addition, SCs have the peculiar ability to foster axonal regrowth after a lesion by demyelinating and converting into repair cells that secrete neurotrophic factors and guide axons back to their former target to finally remyelinate regenerated axons. The different steps of SC development and their role in the maintenance of PNS integrity and regeneration after lesion are controlled by various factors among which transcription factors and chromatin-remodeling enzymes hold major functions. In this review, we discussed how histone modifications and histone-modifying enzymes control SC development, maintenance of PNS integrity and response to injury. The functions of histone modifiers as part of chromatin-remodeling complexes are discussed in another review published in the same issue of Glia.
DDC: 570 Biowissenschaften
570 Life sciences
Institution: Johannes Gutenberg-Universität Mainz
Department: FB 10 Biologie
Place: Mainz
Version: Published version
Publication type: Zeitschriftenaufsatz
License: CC BY
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Journal: Glia
Pages or article number: 1584
Publisher: Wiley-Liss
Publisher place: Bognor Regis u.a.
Issue date: 2020
ISSN: 1098-1136
Publisher URL:
Publisher DOI: 10.1002/glia.23795
Appears in collections:JGU-Publikationen

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