Functions of histone modifications and histone modifiers in Schwann cells

dc.contributor.authorDuman, Mert
dc.contributor.authorMartinez-Moreno, Margot
dc.contributor.authorJacob, Claire
dc.contributor.authorTapinos, Nikos
dc.date.accessioned2021-08-06T07:55:17Z
dc.date.available2021-08-06T07:55:17Z
dc.date.issued2020
dc.description.abstractSchwann cells (SCs) are the main glial cells present in the peripheral nervous system (PNS). Their primary functions are to insulate peripheral axons to protect them from the environment and to enable fast conduction of electric signals along big caliber axons by enwrapping them in a thick myelin sheath rich in lipids. In addition, SCs have the peculiar ability to foster axonal regrowth after a lesion by demyelinating and converting into repair cells that secrete neurotrophic factors and guide axons back to their former target to finally remyelinate regenerated axons. The different steps of SC development and their role in the maintenance of PNS integrity and regeneration after lesion are controlled by various factors among which transcription factors and chromatin-remodeling enzymes hold major functions. In this review, we discussed how histone modifications and histone-modifying enzymes control SC development, maintenance of PNS integrity and response to injury. The functions of histone modifiers as part of chromatin-remodeling complexes are discussed in another review published in the same issue of Glia.en_GB
dc.identifier.doihttp://doi.org/10.25358/openscience-6240
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/6250
dc.language.isoengde
dc.rightsCC-BY-4.0*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.ddc570 Biowissenschaftende_DE
dc.subject.ddc570 Life sciencesen_GB
dc.titleFunctions of histone modifications and histone modifiers in Schwann cellsen_GB
dc.typeZeitschriftenaufsatzde
jgu.journal.issue8de
jgu.journal.titleGliade
jgu.journal.volume68de
jgu.organisation.departmentFB 10 Biologiede
jgu.organisation.nameJohannes Gutenberg-Universität Mainz
jgu.organisation.number7970
jgu.organisation.placeMainz
jgu.organisation.rorhttps://ror.org/023b0x485
jgu.pages.end1595de
jgu.pages.start1584de
jgu.publisher.doi10.1002/glia.23795
jgu.publisher.issn1098-1136de
jgu.publisher.nameWiley-Lissde
jgu.publisher.placeBognor Regis u.a.de
jgu.publisher.urihttps://doi.org/10.1002/glia.23795de
jgu.publisher.year2020
jgu.rights.accessrightsopenAccess
jgu.subject.ddccode570de
jgu.type.dinitypeArticleen_GB
jgu.type.resourceTextde
jgu.type.versionPublished versionde

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