Authors:	Santos, Thiago dos Grundke, Caroline Lucas, Tobias Großmann, Luca Closoki, Giuliano Cesar Opatz, Till
Title:	Glucose as an eco-friendly reductant in a one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones
Online publication date:	6-Jul-2021
Year of first publication:	2020
Language:	english
Abstract:	Carbohydrates such as glucose are an abundant renewable resource that can be employed in synthetic processes as a source of carbon and/or hydrogen to yield products of high economical and biological impact. Herein, we report a versatile and environmentally friendly protocol for the one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones, a privileged scaffold in medicinal chemistry, based on the use of glucose as an eco-friendly reductant in alkaline aqueous medium. This method can be viewed as a blueprint for the development of further one-pot sequences involving glucose as a reductant.
DDC:	540 Chemie 540 Chemistry and allied sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 09 Chemie, Pharmazie u. Geowissensch.
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-6174
Version:	Published version
Publication type:	Zeitschriftenaufsatz
License:	CC BY-NC-ND
Information on rights of use:	https://creativecommons.org/licenses/by-nc-nd/4.0/
Journal:	European journal of organic chemistry 2020 41
Pages or article number:	6429 6432
Publisher:	Wiley-VCH
Publisher place:	Weinheim
Issue date:	2020
ISSN:	1099-0690
Publisher URL:	https://doi.org/10.1002/ejoc.202000970
Publisher DOI:	10.1002/ejoc.202000970
Appears in collections:	JGU-Publikationen