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Authors: Santos, Thiago dos
Grundke, Caroline
Lucas, Tobias
Großmann, Luca
Closoki, Giuliano Cesar
Opatz, Till
Title: Glucose as an eco-friendly reductant in a one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones
Online publication date: 6-Jul-2021
Year of first publication: 2020
Language: english
Abstract: Carbohydrates such as glucose are an abundant renewable resource that can be employed in synthetic processes as a source of carbon and/or hydrogen to yield products of high economical and biological impact. Herein, we report a versatile and environmentally friendly protocol for the one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones, a privileged scaffold in medicinal chemistry, based on the use of glucose as an eco-friendly reductant in alkaline aqueous medium. This method can be viewed as a blueprint for the development of further one-pot sequences involving glucose as a reductant.
DDC: 540 Chemie
540 Chemistry and allied sciences
Institution: Johannes Gutenberg-Universität Mainz
Department: FB 09 Chemie, Pharmazie u. Geowissensch.
Place: Mainz
Version: Published version
Publication type: Zeitschriftenaufsatz
License: CC BY-NC-ND
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Journal: European journal of organic chemistry
Pages or article number: 6429
Publisher: Wiley-VCH
Publisher place: Weinheim
Issue date: 2020
ISSN: 1099-0690
Publisher URL:
Publisher DOI: 10.1002/ejoc.202000970
Appears in collections:JGU-Publikationen

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