Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-6174
Authors: | Santos, Thiago dos Grundke, Caroline Lucas, Tobias Großmann, Luca Closoki, Giuliano Cesar Opatz, Till |
Title: | Glucose as an eco-friendly reductant in a one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones |
Online publication date: | 6-Jul-2021 |
Year of first publication: | 2020 |
Language: | english |
Abstract: | Carbohydrates such as glucose are an abundant renewable resource that can be employed in synthetic processes as a source of carbon and/or hydrogen to yield products of high economical and biological impact. Herein, we report a versatile and environmentally friendly protocol for the one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones, a privileged scaffold in medicinal chemistry, based on the use of glucose as an eco-friendly reductant in alkaline aqueous medium. This method can be viewed as a blueprint for the development of further one-pot sequences involving glucose as a reductant. |
DDC: | 540 Chemie 540 Chemistry and allied sciences |
Institution: | Johannes Gutenberg-Universität Mainz |
Department: | FB 09 Chemie, Pharmazie u. Geowissensch. |
Place: | Mainz |
ROR: | https://ror.org/023b0x485 |
DOI: | http://doi.org/10.25358/openscience-6174 |
Version: | Published version |
Publication type: | Zeitschriftenaufsatz |
License: | CC BY-NC-ND |
Information on rights of use: | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
Journal: | European journal of organic chemistry 2020 41 |
Pages or article number: | 6429 6432 |
Publisher: | Wiley-VCH |
Publisher place: | Weinheim |
Issue date: | 2020 |
ISSN: | 1099-0690 |
Publisher URL: | https://doi.org/10.1002/ejoc.202000970 |
Publisher DOI: | 10.1002/ejoc.202000970 |
Appears in collections: | JGU-Publikationen |
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