Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-5812
Authors: | Hobbach, Anastasia J. Closs, Ellen I. |
Title: | Human cationic amino acid transporters are not affected by direct nitros(yl)ation |
Online publication date: | 18-May-2021 |
Year of first publication: | 2020 |
Language: | english |
Abstract: | A direct inhibiting effect of NO on the function of CAT-1 and -2A has been postulated to occur via nitrosylation of cysteine residues in the transporters. Neither the NO donor SNAP nor a mixture of SIN-1 and Spermine NONOate, that generates the strong nitrosating agent N2O3, reduced CAT-mediated L-arginine transport. Direct nitros(yl)ation does either not occur in CATs or does not affect their transport function. A regulatory effect of NO or nitrosating agents on CAT-mediated transport under physiological conditions seems, therefore, unlikely. |
DDC: | 610 Medizin 610 Medical sciences |
Institution: | Johannes Gutenberg-Universität Mainz |
Department: | FB 04 Medizin |
Place: | Mainz |
ROR: | https://ror.org/023b0x485 |
DOI: | http://doi.org/10.25358/openscience-5812 |
Version: | Published version |
Publication type: | Zeitschriftenaufsatz |
License: | CC BY |
Information on rights of use: | https://creativecommons.org/licenses/by/4.0/ |
Journal: | Amino acids 52 |
Pages or article number: | 499 503 |
Publisher: | Springer |
Publisher place: | Wien u.a. |
Issue date: | 2020 |
ISSN: | 1438-2199 |
Publisher URL: | https://doi.org/10.1007/s00726-020-02819-2 |
Publisher DOI: | 10.1007/s00726-020-02819-2 |
Appears in collections: | JGU-Publikationen |
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hobbach_anastasia-human_cationic-20210422213912095.pdf | 639.92 kB | Adobe PDF | View/Open |