Authors:	Hobbach, Anastasia J. Closs, Ellen I.
Title:	Human cationic amino acid transporters are not affected by direct nitros(yl)ation
Online publication date:	18-May-2021
Year of first publication:	2020
Language:	english
Abstract:	A direct inhibiting effect of NO on the function of CAT-1 and -2A has been postulated to occur via nitrosylation of cysteine residues in the transporters. Neither the NO donor SNAP nor a mixture of SIN-1 and Spermine NONOate, that generates the strong nitrosating agent N2O3, reduced CAT-mediated L-arginine transport. Direct nitros(yl)ation does either not occur in CATs or does not affect their transport function. A regulatory effect of NO or nitrosating agents on CAT-mediated transport under physiological conditions seems, therefore, unlikely.
DDC:	610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-5812
Version:	Published version
Publication type:	Zeitschriftenaufsatz
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/4.0/
Journal:	Amino acids 52
Pages or article number:	499 503
Publisher:	Springer
Publisher place:	Wien u.a.
Issue date:	2020
ISSN:	1438-2199
Publisher URL:	https://doi.org/10.1007/s00726-020-02819-2
Publisher DOI:	10.1007/s00726-020-02819-2
Appears in collections:	JGU-Publikationen