Human cationic amino acid transporters are not affected by direct nitros(yl)ation

Hobbach, Anastasia J.; Closs, Ellen I.

Human cationic amino acid transporters are not affected by direct nitros(yl)ation

dc.contributor.author	Hobbach, Anastasia J.
dc.contributor.author	Closs, Ellen I.
dc.date.accessioned	2021-05-18T10:38:07Z
dc.date.available	2021-05-18T10:38:07Z
dc.date.issued	2020
dc.description.abstract	A direct inhibiting effect of NO on the function of CAT-1 and -2A has been postulated to occur via nitrosylation of cysteine residues in the transporters. Neither the NO donor SNAP nor a mixture of SIN-1 and Spermine NONOate, that generates the strong nitrosating agent N2O3, reduced CAT-mediated L-arginine transport. Direct nitros(yl)ation does either not occur in CATs or does not affect their transport function. A regulatory effect of NO or nitrosating agents on CAT-mediated transport under physiological conditions seems, therefore, unlikely.	en_GB
dc.identifier.doi	http://doi.org/10.25358/openscience-5812
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/5821
dc.language.iso	eng	de
dc.rights	CC-BY-4.0	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Human cationic amino acid transporters are not affected by direct nitros(yl)ation	en_GB
dc.type	Zeitschriftenaufsatz	de
jgu.journal.title	Amino acids	de
jgu.journal.volume	52	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.name	Johannes Gutenberg-Universität Mainz
jgu.organisation.number	2700
jgu.organisation.place	Mainz
jgu.organisation.ror	https://ror.org/023b0x485
jgu.pages.end	503	de
jgu.pages.start	499	de
jgu.publisher.doi	10.1007/s00726-020-02819-2
jgu.publisher.issn	1438-2199	de
jgu.publisher.name	Springer	de
jgu.publisher.place	Wien u.a.	de
jgu.publisher.uri	https://doi.org/10.1007/s00726-020-02819-2	de
jgu.publisher.year	2020
jgu.rights.accessrights	openAccess
jgu.subject.ddccode	610	de
jgu.type.dinitype	Article	en_GB
jgu.type.resource	Text	de
jgu.type.version	Published version	de

Files

Original bundle

Now showing 1 - 1 of 1

Name:: hobbach_anastasia-human_cationic-20210422213912095.pdf
Size:: 639.92 KB
Format:: Adobe Portable Document Format
Description:

Download

License bundle

Now showing 1 - 1 of 1

Name:: license.txt
Size:: 3.57 KB
Format:: Item-specific license agreed upon to submission
Description:

Download

Collections

JGU-Publikationen