Authors:	Herzog, David P. Beckmann, Holger Lieb, Klaus Ryu, Soojin Müller, Marianne B.
Title:	Understanding and predicting antidepressant response : using animal models to move toward precision psychiatry
Online publication date:	19-Dec-2018
Year of first publication:	2018
Language:	english
Abstract:	There are two important gaps of knowledge in depression treatment, namely the lack of biomarkers predicting response to antidepressants and the limited knowledge of the molecular mechanisms underlying clinical improvement. However, individually tailored treatment strategies and individualized prescription are greatly needed given the huge socio-economic burden of depression, the latency until clinical improvement can be observed and the response variability to a particular compound. Still, individual patient-level antidepressant treatment outcomes are highly unpredictable. In contrast to other therapeutic areas and despite tremendous efforts during the past years, the genomics era so far has failed to provide biological or genetic predictors of clinical utility for routine use in depression treatment. Specifically, we suggest to 1) shift the focus from the group patterns to individual outcomes, 2) use dimensional classifications such as Research Domain Criteria, 3) envision better planning and improved connections between pre-clinical and clinical studies within translational research units. In contrast to studies in patients, animal models enable both searches for peripheral biosignatures predicting treatment response and in depth analyses of the neurobiological pathways shaping individual antidepressant response in the brain. While there is a considerable number of animal models available aiming at mimicking disease-like conditions such as those seen in depressive disorder, only a limited number of preclinical or truly translational investigations is dedicated to the issue of heterogeneity seen in response to antidepressant treatment. In this mini-review, we provide an overview on the current state of knowledge and propose a framework for successful translational studies into antidepressant treatment response.
DDC:	610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-264
URN:	urn:nbn:de:hebis:77-publ-587206
Version:	Published version
Publication type:	Zeitschriftenaufsatz
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/4.0/
Journal:	Frontiers in psychiatry 9
Pages or article number:	Art. 512
Publisher:	Frontiers Research Foundation
Publisher place:	Lausanne
Issue date:	2018
ISSN:	1664-0640
Publisher URL:	http://dx.doi.org/10.3389/fpsyt.2018.00512
Publisher DOI:	10.3389/fpsyt.2018.00512
Appears in collections:	JGU-Publikationen