Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-187Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Butzbach, Kathrin | - |
| dc.contributor.author | Konhäuser, Matthias | - |
| dc.contributor.author | Fach, Matthias | - |
| dc.contributor.author | Bamberger, Denise N. | - |
| dc.contributor.author | Breitenbach, Benjamin | - |
| dc.contributor.author | Epe, Bernd | - |
| dc.contributor.author | Wich, Peter | - |
| dc.date.accessioned | 2019-08-14T07:54:40Z | - |
| dc.date.available | 2019-08-14T09:54:40Z | - |
| dc.date.issued | 2019 | - |
| dc.identifier.uri | https://openscience.ub.uni-mainz.de/handle/20.500.12030/189 | - |
| dc.description.abstract | In photodynamic therapy (PDT), photosensitizers and light are used to cause photochemically induced cell death. The selectivity and the effectiveness of the phototoxicity in cancer can be increased by a specific uptake of the photosensitizer into tumor cells. A promising target for this goal is the folic acid receptor α (FRα), which is overexpressed on the surface of many tumor cells and mediates an endocytotic uptake. Here, we describe a polysaccharide-based nanoparticle system suitable for targeted uptake and its photochemical and photobiological characterization. The photosensitizer 5, 10, 15, 20-tetraphenyl-21H, 23H-porphyrine (TPP) was encapsulated in spermine- and acetal-modified dextran (SpAcDex) nanoparticles and conjugated with folic acid (FA) on the surface [SpAcDex(TPP)-FA]. The particles are successfully taken up by human HeLa-KB cells, and a light-induced cytotoxicity is observable. An excess of free folate as the competitor for the FRα-mediated uptake inhibits the phototoxicity. In conclusion, folate-modified SpAcDex particles are a promising drug delivery system for a tumor cell targeted photodynamic therapy. | en_GB |
| dc.description.sponsorship | DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin | - |
| dc.language.iso | eng | - |
| dc.rights | CC BY | de_DE |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
| dc.subject.ddc | 610 Medizin | de_DE |
| dc.subject.ddc | 610 Medical sciences | en_GB |
| dc.title | Receptor-mediated uptake of folic acid-functionalized dextran nanoparticles for applications in photodynamic therapy | en_GB |
| dc.type | Zeitschriftenaufsatz | de_DE |
| dc.identifier.urn | urn:nbn:de:hebis:77-publ-591788 | - |
| dc.identifier.doi | http://doi.org/10.25358/openscience-187 | - |
| jgu.type.dinitype | article | - |
| jgu.type.version | Published version | en_GB |
| jgu.type.resource | Text | - |
| jgu.organisation.department | FB 09 Chemie, Pharmazie u. Geowissensch. | - |
| jgu.organisation.number | 7950 | - |
| jgu.organisation.name | Johannes Gutenberg-Universität Mainz | - |
| jgu.rights.accessrights | openAccess | - |
| jgu.journal.title | Polymers | - |
| jgu.journal.volume | 11 | - |
| jgu.journal.issue | 5 | - |
| jgu.pages.alternative | Art. 896 | - |
| jgu.publisher.year | 2019 | - |
| jgu.publisher.name | MDPI | - |
| jgu.publisher.place | Basel | - |
| jgu.publisher.uri | http://dx.doi.org/10.3390/polym11050896 | - |
| jgu.publisher.issn | 2073-4360 | - |
| jgu.organisation.place | Mainz | - |
| jgu.subject.ddccode | 610 | - |
| opus.date.accessioned | 2019-08-14T07:54:40Z | - |
| opus.date.modified | 2019-08-14T08:04:11Z | - |
| opus.date.available | 2019-08-14T09:54:40 | - |
| opus.subject.dfgcode | 00-000 | - |
| opus.organisation.string | FB 09: Chemie, Pharmazie und Geowissenschaften: Institut für Pharmazie und Biochemie | de_DE |
| opus.identifier.opusid | 59178 | - |
| opus.institute.number | 0910 | - |
| opus.metadataonly | false | - |
| opus.type.contenttype | Keine | de_DE |
| opus.type.contenttype | None | en_GB |
| opus.affiliated | Konhäuser, Matthias | - |
| opus.affiliated | Breitenbach, Benjamin | - |
| opus.affiliated | Epe, Bernd | - |
| opus.affiliated | Wich, Peter | - |
| jgu.publisher.doi | 10.3390/polym11050896 | |
| jgu.organisation.ror | https://ror.org/023b0x485 | |
| Appears in collections: | JGU-Publikationen | |
