Authors:	Bougas, Lykourgos Byron, Joseph Budker, Dmitry Williams, Jonathan
Title:	Absolute optical chiral analysis using cavity-enhanced polarimetry
Online publication date:	6-Feb-2024
Year of first publication:	2022
Language:	english
Abstract:	Chiral analysis is central for scientific advancement in the fields of chemistry, biology, and medicine. It is also indispensable in the development and quality control of chiral compounds in the chemical and pharmaceutical industries. Here, we present the concept of absolute optical chiral analysis, as enabled by cavity-enhanced polarimetry, which allows for accurate unambiguous enantiomeric characterization and enantiomeric excess determination of chiral compounds within complex mixtures at trace levels, without the need for calibration, even in the gas phase. Our approach and technology enable the absolute postchromatographic chiral analysis of complex gaseous mixtures, the rapid quality control of complex mixtures containing chiral volatile compounds, and the online in situ observation of chiral volatile emissions from a plant under stress.
DDC:	530 Physik 530 Physics
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 08 Physik, Mathematik u. Informatik Helmholtz Institut Mainz
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-10059
Version:	Published version
Publication type:	Zeitschriftenaufsatz
Document type specification:	Scientific article
License:	CC BY-NC
Information on rights of use:	https://creativecommons.org/licenses/by-nc/4.0/
Journal:	Science advances 8 22
Pages or article number:	eabm3749
Publisher:	American Association for the Advancement of Science
Publisher place:	Washington, DC u.a.
Issue date:	2022
ISSN:	2375-2548
Publisher DOI:	10.1126/sciadv.abm3749
Appears in collections:	DFG-491381577-G