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Authors: Van Dyke, Erik T.
Eills, James
Picazo-Frutos, Román
Sheberstov, Kirill F.
Hu, Yinan
Budker, Dmitry
Barskiy, Danila A.
Title: Relayed hyperpolarization for zero-field nuclear magnetic resonance
Online publication date: 6-Feb-2024
Year of first publication: 2022
Language: english
Abstract: Zero- to ultralow-field nuclear magnetic resonance (ZULF NMR) is a rapidly developing form of spectroscopy that provides rich spectroscopic information in the absence of large magnetic fields. However, signal acquisition still requires a mechanism for generating a bulk magnetic moment for detection, and the currently used methods only apply to a limited pool of chemicals or come at prohibitively high cost. We demonstrate that the parahydrogen-based SABRE (signal amplification by reversible exchange)–Relay method can be used as a more general means of generating hyperpolarized analytes for ZULF NMR by observing zero-field J-spectra of [13C]-methanol, [1-13C]-ethanol, and [2-13C]-ethanol in both 13C-isotopically enriched and natural abundance samples. We explore the magnetic field dependence of the SABRE-Relay efficiency and show the existence of a second maximum at 19.0 ± 0.3 mT. Despite presence of water, SABRE-Relay is used to hyperpolarize ethanol extracted from a store-bought sample of vodka (%PH ~ 0.1%).
DDC: 530 Physik
530 Physics
Institution: Johannes Gutenberg-Universität Mainz
Department: FB 08 Physik, Mathematik u. Informatik
Helmholtz Institut Mainz
Place: Mainz
Version: Published version
Publication type: Zeitschriftenaufsatz
Document type specification: Scientific article
License: CC BY-NC
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Journal: Science advances
Pages or article number: eabp9242
Publisher: American Association for the Advancement of Science
Publisher place: Washington, DC u.a.
Issue date: 2022
ISSN: 2375-2548
Publisher DOI: 10.1126/sciadv.abp9242
Appears in collections:DFG-491381577-G

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