Authors:	Van Dyke, Erik T. Eills, James Picazo-Frutos, Román Sheberstov, Kirill F. Hu, Yinan Budker, Dmitry Barskiy, Danila A.
Title:	Relayed hyperpolarization for zero-field nuclear magnetic resonance
Online publication date:	6-Feb-2024
Year of first publication:	2022
Language:	english
Abstract:	Zero- to ultralow-field nuclear magnetic resonance (ZULF NMR) is a rapidly developing form of spectroscopy that provides rich spectroscopic information in the absence of large magnetic fields. However, signal acquisition still requires a mechanism for generating a bulk magnetic moment for detection, and the currently used methods only apply to a limited pool of chemicals or come at prohibitively high cost. We demonstrate that the parahydrogen-based SABRE (signal amplification by reversible exchange)–Relay method can be used as a more general means of generating hyperpolarized analytes for ZULF NMR by observing zero-field J-spectra of [13C]-methanol, [1-13C]-ethanol, and [2-13C]-ethanol in both 13C-isotopically enriched and natural abundance samples. We explore the magnetic field dependence of the SABRE-Relay efficiency and show the existence of a second maximum at 19.0 ± 0.3 mT. Despite presence of water, SABRE-Relay is used to hyperpolarize ethanol extracted from a store-bought sample of vodka (%PH ~ 0.1%).
DDC:	530 Physik 530 Physics
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 08 Physik, Mathematik u. Informatik Helmholtz Institut Mainz
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-10058
Version:	Published version
Publication type:	Zeitschriftenaufsatz
Document type specification:	Scientific article
License:	CC BY-NC
Information on rights of use:	https://creativecommons.org/licenses/by-nc/4.0/
Journal:	Science advances 8 29
Pages or article number:	eabp9242
Publisher:	American Association for the Advancement of Science
Publisher place:	Washington, DC u.a.
Issue date:	2022
ISSN:	2375-2548
Publisher DOI:	10.1126/sciadv.abp9242
Appears in collections:	DFG-491381577-G