Boosting T cell immunity against cytomegalovirus : a potential strategy combating human aging and age-related diseases
Date issued
Editors
Journal Title
Journal ISSN
Volume Title
Publisher
License
Abstract
In a recent publication in Cell, Hasegawa and colleagues reveal that
cytotoxic CD4-positive cytotoxic T lymphocytes (CD4+ CTLs)
eliminate senescent fibroblasts with a surface expression of the
immunologically important human leukocyte antigen class II (HLA-II)
and the human cytomegalovirus glycoprotein B (HCMV-gB).1 This
implies that a virome-immune cell interaction controls the fate of
human skin cells that are linked to the aging process and associated
diseases.
Description
Keywords
Citation
Published in
Signal transduction and targeted therapy, 8, Macmillan Publishers, part of Springer Nature, London, 2023, https://doi.org/10.1038/s41392-023-01590-6