Boosting T cell immunity against cytomegalovirus : a potential strategy combating human aging and age-related diseases

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2023

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Abstract

In a recent publication in Cell, Hasegawa and colleagues reveal that cytotoxic CD4-positive cytotoxic T lymphocytes (CD4+ CTLs) eliminate senescent fibroblasts with a surface expression of the immunologically important human leukocyte antigen class II (HLA-II) and the human cytomegalovirus glycoprotein B (HCMV-gB).1 This implies that a virome-immune cell interaction controls the fate of human skin cells that are linked to the aging process and associated diseases.

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http://doi.org/10.25358/openscience-10008

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https://openscience.ub.uni-mainz.de/handle/20.500.12030/10026

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Signal transduction and targeted therapy, 8, Macmillan Publishers, part of Springer Nature, London, 2023, https://doi.org/10.1038/s41392-023-01590-6

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