Authors:	Wirth, Matthias Brenner, Walburgis Krämer, Oliver H.
Title:	Boosting T cell immunity against cytomegalovirus : a potential strategy combating human aging and age-related diseases
Online publication date:	14-Feb-2024
Year of first publication:	2023
Language:	english
Abstract:	In a recent publication in Cell, Hasegawa and colleagues reveal that cytotoxic CD4-positive cytotoxic T lymphocytes (CD4+ CTLs) eliminate senescent fibroblasts with a surface expression of the immunologically important human leukocyte antigen class II (HLA-II) and the human cytomegalovirus glycoprotein B (HCMV-gB).1 This implies that a virome-immune cell interaction controls the fate of human skin cells that are linked to the aging process and associated diseases.
DDC:	610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-10008
Version:	Published version
Publication type:	Zeitschriftenaufsatz
Document type specification:	Scientific article
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/4.0/
Journal:	Signal transduction and targeted therapy 8
Pages or article number:	325
Publisher:	Macmillan Publishers, part of Springer Nature
Publisher place:	London
Issue date:	2023
ISSN:	2059-3635
Publisher DOI:	10.1038/s41392-023-01590-6
Appears in collections:	DFG-491381577-G