Boosting T cell immunity against cytomegalovirus : a potential strategy combating human aging and age-related diseases

Wirth, Matthias; Brenner, Walburgis; Krämer, Oliver H.

Boosting T cell immunity against cytomegalovirus : a potential strategy combating human aging and age-related diseases

dc.contributor.author	Wirth, Matthias
dc.contributor.author	Brenner, Walburgis
dc.contributor.author	Krämer, Oliver H.
dc.date.accessioned	2024-02-14T10:32:41Z
dc.date.available	2024-02-14T10:32:41Z
dc.date.issued	2023
dc.description.abstract	In a recent publication in Cell, Hasegawa and colleagues reveal that cytotoxic CD4-positive cytotoxic T lymphocytes (CD4+ CTLs) eliminate senescent fibroblasts with a surface expression of the immunologically important human leukocyte antigen class II (HLA-II) and the human cytomegalovirus glycoprotein B (HCMV-gB).1 This implies that a virome-immune cell interaction controls the fate of human skin cells that are linked to the aging process and associated diseases.	en_GB
dc.description.sponsorship	Deutsche Forschungsgemeinschaft (DFG)\|491381577\|Open-Access-Publikationskosten 2022–2024 Universität Mainz - Universitätsmedizin
dc.identifier.doi	http://doi.org/10.25358/openscience-10008
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/10026
dc.language.iso	eng	de
dc.rights	CC-BY-4.0	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Boosting T cell immunity against cytomegalovirus : a potential strategy combating human aging and age-related diseases	en_GB
dc.type	Zeitschriftenaufsatz	de
jgu.journal.title	Signal transduction and targeted therapy	de
jgu.journal.volume	8	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.name	Johannes Gutenberg-Universität Mainz
jgu.organisation.number	2700
jgu.organisation.place	Mainz
jgu.organisation.ror	https://ror.org/023b0x485
jgu.pages.alternative	325	de
jgu.publisher.doi	10.1038/s41392-023-01590-6	de
jgu.publisher.issn	2059-3635	de
jgu.publisher.name	Macmillan Publishers, part of Springer Nature	de
jgu.publisher.place	London	de
jgu.publisher.year	2023
jgu.rights.accessrights	openAccess
jgu.subject.ddccode	610	de
jgu.subject.dfg	Lebenswissenschaften	de
jgu.type.contenttype	Scientific article	de
jgu.type.dinitype	Article	en_GB
jgu.type.resource	Text	de
jgu.type.version	Published version	de

Files

Original bundle

Now showing 1 - 1 of 1

Name:: boosting_t_cell_immunity_agai-20240201162630387.pdf
Size:: 590.3 KB
Format:: Adobe Portable Document Format
Description:

Download

License bundle

Now showing 1 - 1 of 1

Name:: license.txt
Size:: 3.57 KB
Format:: Item-specific license agreed upon to submission
Description:

Download

Collections

DFG-491381577-G