A total synthesis of (−)-strychnine using photoredox catalysis
Loading...
Date issued
Editors
Journal Title
Journal ISSN
Volume Title
Publisher
Reuse License
Abstract
A concise route toward (−)-strychnine is presented. Key steps include the photoredox-catalytic C2-cyanomethylation of Boc-l-Trp-OMe and a condensation-electrocyclization cascade linking two fragments convergently to obtain an advanced intermediate. A photochemical decarboxylation provided convenient access to strychnofluorine, which could be transformed through the Wieland–Gumlich aldehyde to strychnine. All building blocks can be traced back to renewable sources.
Description
Keywords
Citation
Published in
JACS Au : an open access journal of the American Chemical Society, 6, 3, ACS, Washington, DC, 2026, https://doi.org/10.1021/jacsau.5c01709