Authors:	Schneider, Johannes Blum, Stephan P. Waldvogel, Siegfried R.
Title:	Electrochemical synthesis of sulfonamides in single-pass flow
Online publication date:	11-Dec-2023
Year of first publication:	2023
Language:	english
Abstract:	An electrochemical multicomponent synthesis of sulfonamides at room temperature in single-pass flow is presented. In contrast to batch-type electrolysis, an undivided flow cell setup with a stainless-steel cathode and either a boron-doped diamond (BDD) anode or a glassy carbon anode can be employed. Simply by using SO2 stock solutions, less atom-economic sulfur dioxide surrogates can be avoided. Moreover, no additional supporting electrolytes are required due to the in-situ generation of amidosulfinates, which also serve as intermediate for this transformation. This protocol allows sulfonamides to be synthesized directly from non-prefunctionalized electron-rich arenes with amines and SO2. In total, 10 examples are demonstrated with isolated yields up to 92 %. The robust scalability of this electrosynthesis with an easy downstream processing was also proven.
DDC:	540 Chemie 540 Chemistry and allied sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 09 Chemie, Pharmazie u. Geowissensch.
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-9785
Version:	Published version
Publication type:	Zeitschriftenaufsatz
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/4.0/
Journal:	ChemElectroChem 10 23
Pages or article number:	e202300456
Publisher:	Wiley-VCH
Publisher place:	Weinheim
Issue date:	2023
ISSN:	2196-0216
Publisher DOI:	10.1002/celc.202300456
Appears in collections:	DFG-491381577-G