Authors:	Hofmann, Silja Winter, Johannes Prenzel, Tobias de Jesús Gálvez-Vázquez, María Waldvogel, Siegfried R.
Title:	Electrochemical synthesis of isoxazoles and isoxazolines via anodic oxidation of oximes
Online publication date:	5-Dec-2023
Year of first publication:	2023
Language:	english
Abstract:	Isoxazol(in)es are widely featured structural motifs in natural products, agrochemicals, and pharmaceuticals. The first intermolecular approach for a direct electrochemical synthesis from readily available aldoximes is reported. Isoxazoles and isoxazolines were obtained in yields up to 81 %. The synthesis is carried out in an undivided cell as the simplest electrochemical set-up and requires only the use of electric current as traceless oxidizing agent. The application of inexpensive and widely available electrode materials in combination with recyclable supporting electrolytes and solvents paves the path for translation of the presented reaction onto preparative scale. This is underlined by successful scale-up to multi-gram runs.
DDC:	540 Chemie 540 Chemistry and allied sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 09 Chemie, Pharmazie u. Geowissensch.
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-9752
Version:	Published version
Publication type:	Zeitschriftenaufsatz
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/4.0/
Journal:	ChemElectroChem 10 22
Pages or article number:	e202300434
Publisher:	Wiley-VCH
Publisher place:	Weinheim
ISSN:	2196-0216
Publisher DOI:	10.1002/celc.202300434
Appears in collections:	DFG-491381577-G