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Authors: Erdogan, Betül R.
Michel, Martina B.
Matthes, Jan
Castañeda, Tamara R.
Christen, Urs
Arioglu-Inan, Ebru
Michel, Martin C.
Pautz, Andrea
Title: A comparison of urinary bladder weight in male and female mice across five models of diabetes and obesity
Online publication date: 26-May-2023
Year of first publication: 2023
Language: english
Abstract: Introduction: Diabetes often leads to lower urinary tract dysfunction. The most frequently assessed parameter of urinary bladder dysfunction in animal models of diabetes is an enlargement of the bladder, which is consistently observed in type 1 and less consistently in type 2 diabetes. The vast majority of studies on bladder weight in animal models of diabetes and obesity has been performed in males, and no studies have directly compared this outcome parameter between sexes. Methods: Therefore, we have compared bladder weight and bladder/body weight ratio in five mouse models of obesity and diabetes (RIP-LCMV, db/db, ob/ob (two studies), insulin receptor substrate 2 (IRS2) knock-out mice and mice on a high-fat diet; pre-specified secondary analysis of a previously reported study). Results: In a pooled analysis of the control groups of all studies, females exhibited slightly lower glucose levels, lower body weight, and lower bladder weight, but bladder/body weight ratio was similar in both sexes (0.957 vs. 0.986 mg/g, mean difference 0.029 [−0.06; 0.118]). Among the six diabetic/obese groups, bladder/body weight ratio was similar in both sexes in three but smaller in female mice in three other groups. The mRNA expression of a panel of genes implied in the pathophysiology of bladder enlargement and/or fibrosis and inflammation did not differ systematically between sexes. Conclusions: We conclude that sex differences in diabetes/obesity-associated bladder enlargement may be model dependent.
DDC: 610 Medizin
610 Medical sciences
Institution: Johannes Gutenberg-Universität Mainz
Department: FB 04 Medizin
Place: Mainz
Version: Published version
Publication type: Zeitschriftenaufsatz
Document type specification: Scientific article
License: CC BY
Information on rights of use:
Journal: Frontiers in pharmacology
Pages or article number: 1118730
Publisher: Frontiers Media
Publisher place: Lausanne
Issue date: 2023
ISSN: 1663-9812
Publisher URL:
Publisher DOI: 10.3389/fphar.2023.1118730
Appears in collections:DFG-491381577-G

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