Authors:	Gadelshin, Vadim Maratovich Formento Cavaier, Roberto Haddad, Ferid Heinke, Reinhard Stora, Thierry Studer, Dominik Weber, Felix Wendt, Klaus
Title:	Terbium medical radioisotope production : laser resonance ionization scheme development
Online publication date:	2-Mar-2023
Year of first publication:	2021
Language:	english
Abstract:	Terbium (Tb) is a promising element for the theranostic approach in nuclear medicine. The new CERN-MEDICIS facility aims for production of its medical radioisotopes to support related R&D projects in biomedicine. The use of laser resonance ionization is essential to provide radioisotopic yields of highest quantity and quality, specifically regarding purity. This paper presents the results of preparation and characterization of a suitable two-step laser resonance ionization process for Tb. By resonance excitation via an auto-ionizing level, the high ionization efficiency of 53% was achieved. To simulate realistic production conditions for Tb radioisotopes, the influence of a surplus of Gd atoms, which is a typical target material for Tb generation, was considered, showing the necessity of radiochemical purification procedures before mass separation. Nevertheless, a 10-fold enhancement of the Tb ion beam using laser resonance ionization was observed even with Gd:Tb atomic ratio of 100:1.
DDC:	530 Physik 530 Physics 610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 08 Physik, Mathematik u. Informatik
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-8872
Version:	Published version
Publication type:	Zeitschriftenaufsatz
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/4.0/
Journal:	Frontiers in medicine 8
Pages or article number:	727557
Publisher:	Frontiers Media
Publisher place:	Lausanne
Issue date:	2021
ISSN:	2296-858X
Publisher DOI:	10.3389/fmed.2021.727557
Appears in collections:	JGU-Publikationen