Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-8872
Authors: | Gadelshin, Vadim Maratovich Formento Cavaier, Roberto Haddad, Ferid Heinke, Reinhard Stora, Thierry Studer, Dominik Weber, Felix Wendt, Klaus |
Title: | Terbium medical radioisotope production : laser resonance ionization scheme development |
Online publication date: | 2-Mar-2023 |
Year of first publication: | 2021 |
Language: | english |
Abstract: | Terbium (Tb) is a promising element for the theranostic approach in nuclear medicine. The new CERN-MEDICIS facility aims for production of its medical radioisotopes to support related R&D projects in biomedicine. The use of laser resonance ionization is essential to provide radioisotopic yields of highest quantity and quality, specifically regarding purity. This paper presents the results of preparation and characterization of a suitable two-step laser resonance ionization process for Tb. By resonance excitation via an auto-ionizing level, the high ionization efficiency of 53% was achieved. To simulate realistic production conditions for Tb radioisotopes, the influence of a surplus of Gd atoms, which is a typical target material for Tb generation, was considered, showing the necessity of radiochemical purification procedures before mass separation. Nevertheless, a 10-fold enhancement of the Tb ion beam using laser resonance ionization was observed even with Gd:Tb atomic ratio of 100:1. |
DDC: | 530 Physik 530 Physics 610 Medizin 610 Medical sciences |
Institution: | Johannes Gutenberg-Universität Mainz |
Department: | FB 08 Physik, Mathematik u. Informatik |
Place: | Mainz |
ROR: | https://ror.org/023b0x485 |
DOI: | http://doi.org/10.25358/openscience-8872 |
Version: | Published version |
Publication type: | Zeitschriftenaufsatz |
License: | CC BY |
Information on rights of use: | https://creativecommons.org/licenses/by/4.0/ |
Journal: | Frontiers in medicine 8 |
Pages or article number: | 727557 |
Publisher: | Frontiers Media |
Publisher place: | Lausanne |
Issue date: | 2021 |
ISSN: | 2296-858X |
Publisher DOI: | 10.3389/fmed.2021.727557 |
Appears in collections: | JGU-Publikationen |
Files in This Item:
File | Description | Size | Format | ||
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![]() | terbium_medical_radioisotope_-20230302114130444.pdf | 3.34 MB | Adobe PDF | View/Open |