Authors:	Aghayeva, Fidan A. Schuster, Alexander K. Diel, Heidi Chronopoulos, Panagiotis Wagner, Felix M. Grehn, Franz Pirlich, Nina Schweiger, Susann Pfeiffer, Norbert Hoffmann, Esther M.
Title:	Childhood glaucoma registry in Germany : initial database, clinical care and research (pilot study)
Online publication date:	3-Feb-2023
Year of first publication:	2022
Language:	english
Abstract:	Objective The aim of this prospective pilot study is to establish an initial database to register patients diagnosed with different types of childhood glaucoma and the set-up of a national registry for childhood glaucoma (ReCG) in Germany. 28 children with different types of diagnosed childhood glaucoma, who were admitted and treated at the Childhood Glaucoma Center of the University Medical Center Mainz, Germany were included. Main outcome measures were the type of childhood glaucoma, mean intraocular pressure (IOP) and genetic data of the patients. Results The documents and questionnaires for each individual included: informed consent form of the parents, medical history form of the child, patient’s gestational history questionnaire and general anesthesia examination form. Primary congenital and secondary childhood glaucoma were revealed in 11 (39%) and 17 (61%) patients, respectively. The mean IOP measured with Perkins tonometer in all patients under general anesthesia at the time of inclusion was 17.5 ± 11.8 mmHg in the right and 17 ± 8.9 mmHg in the left eyes. In 33% of children with glaucoma mutations in the CYP1B1, FOXC1, LTBP2 and TEK genes were found. The development of specific questionnaires for childhood glaucoma provides detailed baseline data to establish a ReCG in Germany for the first time.
DDC:	610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-8754
Version:	Published version
Publication type:	Zeitschriftenaufsatz
Document type specification:	Scientific article
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/4.0/
Journal:	BMC Research Notes 15
Pages or article number:	32
Publisher:	BMC
Publisher place:	London
Issue date:	2022
ISSN:	1756-0500
Publisher DOI:	10.1186/s13104-022-05921-8
Appears in collections:	DFG-491381577-G