Gutenberg Open Science: Temporal trends in patients with peripheral artery disease influenced by diabetes mellitus in Germany

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-8726

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DC Field	Value	Language
dc.contributor.author	Schmitt, Volker H.	-
dc.contributor.author	Hobohm, Lukas	-
dc.contributor.author	Vosseler, Markus	-
dc.contributor.author	Brochhausen, Christoph	-
dc.contributor.author	Münzel, Thomas	-
dc.contributor.author	Espinola-Klein, Christine	-
dc.contributor.author	Keller, Karsten	-
dc.date.accessioned	2023-02-03T10:54:26Z	-
dc.date.available	2023-02-03T10:54:26Z	-
dc.date.issued	2022	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/8742	-
dc.description.abstract	Introduction In patients with peripheral artery disease (PAD) the presence of diabetes mellitus (DM) is associated with higher morbidity and mortality. Because huge efforts are made to improve medical care of patients with DM including chronic disease programs, the aim of the present study was to investigate temporal trends regarding the clinical burden of DM on PAD patients within a 15-year observational period. Methods We analyzed all patients hospitalized because of PAD between 2005 and 2019 in Germany stratified regarding DM. Results Overall, 2 654 871 hospitalizations of PAD patients (865 823 with DM) were included. Hospitalizations based on PAD inclined from 142 778 in 2005 to 190 135 in 2019 (β 3956 per year; 95% confidence interval [CI] 3034–4878, p < .001) with simultaneous increase of hospitalizations of PAD patients with DM (2005: 41609 (29.1%) versus 2019: 65 302 (34.3%); β 2019 per year [95% CI 1593–2446], p < .001). Amputation rates (β −0.42 [95% CI −0.44 to −0.40]; p < .001) as well as in-hospital case-fatality rate (2005: 4.7%, 2019: 2.8%; β −0.64 [95% CI −0.69 to −0.59]; p < .001) decreased in diabetic PAD patients during the observational time. In spite of improved morbidity and mortality in the last years of the observational period, patients with DM still suffered from an increased risk for morbidity and mortality during the observational period compared to nondiabetic PAD patients. Conclusions Despite the progress in DM treatments, DM still was associated with an unfavorable clinical patient profile and remained a substantial risk factor for morbidity and mortality in hospitalized patients with PAD and DM in Germany between 2005 and 2019.	en_GB
dc.description.sponsorship	Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 491381577	de
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Temporal trends in patients with peripheral artery disease influenced by diabetes mellitus in Germany	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-8726	-
jgu.type.contenttype	Scientific article	de
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Journal of diabetes	de
jgu.journal.volume	14	de
jgu.journal.issue	10	de
jgu.pages.start	670	de
jgu.pages.end	684	de
jgu.publisher.year	2022	-
jgu.publisher.name	Wiley-Blackwell	de
jgu.publisher.place	Oxford u.a	de
jgu.publisher.issn	1753-0393	de
jgu.publisher.issn	1753-0407	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
jgu.publisher.doi	10.1111/1753-0407.13316	de
jgu.organisation.ror	https://ror.org/023b0x485	-
jgu.subject.dfg	Lebenswissenschaften	de
Appears in collections:	DFG-491381577-G

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