Authors:	Keller, Karsten Geyer, Martin Hobohm, Lukas Tamm, Alexander R. Kreidel, Felix Ruf, Tobias F. Hell, Michaela Schmitt, Volker H. Bachmann, Kevin Born, Sonja Schulz, Eberhard Münzel, Thomas Bardeleben, Ralph S. von
Title:	Survival benefit of overweight patients undergoing MitraClip® procedure in comparison to normal-weight patients
Online publication date:	3-Feb-2023
Year of first publication:	2022
Language:	english
Abstract:	Background The number of MitraClip® implantations increased significantly in recent years. Data regarding the impact of weight class on survival are sparse. Hypothesis We hypothesized that weight class influences survival of patients treated with MitraClip® implantation. Methods We investigated in-hospital, 1-year, 3-year, and long-term survival of patients successfully treated with isolated MitraClip® implantation for mitral valve regurgitation (MR) (June 2010–March 2018). Patients were categorized by weight classes, and the impact of weight classes on survival was analyzed. Results Of 617 patients (aged 79.2 years; 47.3% females) treated with MitraClip® implantation (June 2010–March 2018), 12 patients were underweight (2.2%), 220 normal weight (40.1%), 237 overweight (43.2%), and 64 obesity class I (11.7%), 12 class II (2.2%), and 4 class III (0.7%). Preprocedural Logistic EuroScore (21.1 points [IQR 14.0–37.1]; 26.0 [18.5–38.5]; 26.0 [18.4–39.9]; 24.8 [16.8–33.8]; 33.0 [25.9–49.2]; 31.6 [13.1–47.6]; p = .291) was comparable between groups. Weight class had no impact on in-hospital death (0.0%; 4.1%; 1.5%; 0.0%; 7.7%; 0.0%; p = .189), 1-year survival (75.0%; 72.0%; 76.9%; 75.0%; 75.0%; 33.3%; p = .542), and 3-year survival (40.0%; 36.8%; 38.2%; 48.6%; 20.0%; 33.3%; p = .661). Compared to normal weight, underweight (hazard ratio [HR]: 1.35 [95% confidence interval [CI]: 0.65–2.79], p = .419), obesity-class I (HR: 0.93 [95% CI: 0.65–1.34], p = .705), class II (HR: 0.39 [95% CI: 0.12–1.24], p = .112), and class III (HR: 1.28 [95% CI: 0.32–5.21], p = .726) did not affect long-term survival. In contrast, overweight was associated with better survival (HR: 1.32 [95% CI: 1.04–1.68], p = .023). Conclusion Overweight affected the long-term survival of patients undergoing MitraClip® implantation beneficially compared to normal weight.
DDC:	610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-8725
Version:	Published version
Publication type:	Zeitschriftenaufsatz
Document type specification:	Scientific article
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/4.0/
Journal:	Clinical cardiology 45 12
Pages or article number:	1236 1245
Publisher:	Wiley
Publisher place:	Weinheim u.a.
Issue date:	2022
ISSN:	1932-8737
Publisher DOI:	10.1002/clc.23897
Appears in collections:	DFG-491381577-G