Authors:	Galata, Christian Messerschmidt, Antje Kostic, Marko Karampinis, Ioannis Roessner, Eric El Beyrouti, Hazem Schneider, Thomas Stamenovic, Davor
Title:	Prognostic factors for long-term survival following complete resection by lobectomy in stage I non-small cell lung cancer
Online publication date:	3-Feb-2023
Year of first publication:	2022
Language:	english
Abstract:	Background The aim of this study was to evaluate predictors for long-term overall survival (OS) in patients with stage I non-small cell lung cancer (NSCLC). Methods All patients undergoing complete resection by lobectomy for stage I NSCLC between October 2012 and December 2015 at a single center were included. Univariable and multivariable Cox regression analyses were performed to identify prognostic factors. Results A total of 92 patients were included. Univariable and multivariable Cox regression analyses revealed preoperative neutrophil to lymphocyte ratio (NLR, p = 0.005), preoperative diffusion capacity of the lungs for carbon monoxide (DLCO, p = 0.010) and forced expiratory volume in 1 second (FEV1, p = 0.041) as well as male gender (p = 0.026) as independent prognostic factors for OS. Combining the calculated cutoff values for FEV1 (<73.0%) and NLR (>3.49) into one parameter resulted in a highly significant difference in survival times when stratified by this variable. Conclusions Recently, much emphasis has been put on the prognostic importance of blood biomarkers in NSCLC. In our study, NLR was an independent factor for OS, as were baseline characteristics such as DLCO, FEV1, and gender. Further studies on the association of biomarkers for systemic inflammation and lung function parameters with respect to patient survival are warranted.
DDC:	610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-8723
Version:	Published version
Publication type:	Zeitschriftenaufsatz
Document type specification:	Scientific article
License:	CC BY-NC-ND
Information on rights of use:	https://creativecommons.org/licenses/by-nc-nd/4.0/
Journal:	Thoracic cancer 13 20
Pages or article number:	2861 2866
Publisher:	Wiley-Blackwell
Publisher place:	Hoboken, NJ u.a.
Issue date:	2022
ISSN:	1759-7706 1759-7714
Publisher DOI:	10.1111/1759-7714.14630
Appears in collections:	DFG-491381577-G