Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-8683Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Sohl, Julian | - |
| dc.contributor.author | Hartmann, Ann-Kathrin | - |
| dc.contributor.author | Hahlbrock, Jennifer | - |
| dc.contributor.author | Bartneck, Joschka | - |
| dc.contributor.author | Stassen, Michael | - |
| dc.contributor.author | Klein, Matthias | - |
| dc.contributor.author | Bros, Matthias | - |
| dc.contributor.author | Grabbe, Stephan | - |
| dc.contributor.author | Marini, Federico | - |
| dc.contributor.author | Woods, Kevin | - |
| dc.contributor.author | Guezguez, Borhane | - |
| dc.contributor.author | Mack, Matthias | - |
| dc.contributor.author | Schild, Hansjörg | - |
| dc.contributor.author | Muth, Sabine | - |
| dc.contributor.author | Melchior, Felix | - |
| dc.contributor.author | Probst, Hans Christian | - |
| dc.contributor.author | Langguth, Peter | - |
| dc.contributor.author | Radsak, Markus P. | - |
| dc.date.accessioned | 2023-02-13T11:25:55Z | - |
| dc.date.available | 2023-02-13T11:25:55Z | - |
| dc.date.issued | 2022 | - |
| dc.identifier.uri | https://openscience.ub.uni-mainz.de/handle/20.500.12030/8699 | - |
| dc.description.abstract | Transcutaneous immunization (TCI) utilizing the TLR7 agonist imiquimod (IMQ-TCI) induces T cell-driven protective immunity upon application onto intact skin. In our present work, we combine the anti-psoriatic agent dithranol with IMQ-TCI to boost vaccination efficacy (Dithranol/IMQ-based transcutaneous vaccination (DIVA)). Using ovalbumin-derived peptides as model antigens in mice, DIVA induced superior cytolytic CD8+ T cells and CD4+ T cells with a TH1 cytokine profile in the priming as well as in the memory phase. Regarding the underlying mechanisms, dithranol induced an oxidant-dependent, monocyte-attracting inflammatory milieu in the skin boosting TLR7-dependent activation of dendritic cells and macrophages leading to superior T cell priming and protective immunity in vaccinia virus infection. In conclusion, we introduce the non-invasive vaccination method DIVA to induce strong primary and memory T cell responses upon a single local treatment. This work provides relevant insights in cutaneous vaccination approaches, paving the way for clinical development in humans. | en_GB |
| dc.description.sponsorship | Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 491381577 | de |
| dc.language.iso | eng | de |
| dc.rights | CC BY | * |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
| dc.subject.ddc | 610 Medizin | de_DE |
| dc.subject.ddc | 610 Medical sciences | en_GB |
| dc.title | Dithranol as novel co-adjuvant for non-invasive dermal vaccination | en_GB |
| dc.type | Zeitschriftenaufsatz | de |
| dc.identifier.doi | http://doi.org/10.25358/openscience-8683 | - |
| jgu.type.contenttype | Scientific article | de |
| jgu.type.dinitype | article | en_GB |
| jgu.type.version | Published version | de |
| jgu.type.resource | Text | de |
| jgu.organisation.department | FB 04 Medizin | de |
| jgu.organisation.number | 2700 | - |
| jgu.organisation.name | Johannes Gutenberg-Universität Mainz | - |
| jgu.rights.accessrights | openAccess | - |
| jgu.journal.title | npj vaccines | de |
| jgu.journal.volume | 7 | de |
| jgu.pages.alternative | 112 | de |
| jgu.publisher.year | 2022 | - |
| jgu.publisher.name | Nature Publishing Group | de |
| jgu.publisher.place | London | de |
| jgu.publisher.issn | 2059-0105 | de |
| jgu.organisation.place | Mainz | - |
| jgu.subject.ddccode | 610 | de |
| jgu.publisher.doi | 10.1038/s41541-022-00530-9 | de |
| jgu.organisation.ror | https://ror.org/023b0x485 | - |
| jgu.subject.dfg | Lebenswissenschaften | de |
| Appears in collections: | DFG-491381577-G | |
Files in This Item:
| File | Description | Size | Format | ||
|---|---|---|---|---|---|
 | dithranol_as_novel_coadjuvant-20230127111116015.pdf | 2.69 MB | Adobe PDF | View/Open |