Authors:	Fieß, Achim Gißler, Sandra Mildenberger, Eva Urschitz, Michael S. Fauer, Agnes Elflein, Heike M. Zepp, Fred Stoffelns, Bernhard Pfeiffer, Norbert Schuster, Alexander K.
Title:	Anterior chamber angle in adults born extremely, very, and moderately preterm with and without retinopathy of prematurity : results of the Gutenberg Prematurity Eye Study
Online publication date:	13-Feb-2023
Year of first publication:	2022
Language:	english
Abstract:	Purpose: To determine whether prematurity and associated factors affect the anterior chamber angle (ACA) width in adulthood. Methods: The Gutenberg Prematurity Eye Study (GPES) is a retrospective cohort study with a prospective ophthalmologic examination of adults (age 18–52 years) in Germany. All participants were examined with Scheimpflug imaging (Pentacam HR, Oculus Optikgeräte GmbH, Wetzlar, Germany) using linear regression analysis to assess the associations of ACA in the different sectors with gestational age (GA), birth weight, birth weight percentile, retinopathy of prematurity (ROP), ROP treatment, placental insufficiency, preeclampsia, and breastfeeding. Results: In total, 516 eyes of 319 preterm and full-term individuals (aged 28.9 ± 8.8 years, 188 females) were examined. ROP treatment was associated with smaller ACA width in the nasal (B = −9.6 [95%CI: −14.7; −4.5] degree; p < 0.001) and temporal positions (B = −11.5 [95%CI: −17.7; −5.3] degree; p = 0.001), whereas non-treated individuals with ROP had an unaltered ACA width, as did individuals with low gestational age without ROP. Conclusion: Advanced stages of ROP following treatment with laser- and cryocoagulation lead to a smaller ACA width until adulthood, and hence may increase the risk of angle closure in later life.
DDC:	610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-8668
Version:	Published version
Publication type:	Zeitschriftenaufsatz
Document type specification:	Scientific article
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/4.0/
Journal:	Children 9 2
Pages or article number:	281
Publisher:	MDPI
Publisher place:	Basel
Issue date:	2022
ISSN:	2227-9067
Publisher DOI:	10.3390/children9020281
Appears in collections:	DFG-491381577-G