Gutenberg Open Science: Extracts of Rheum palmatum and Aloe vera show beneficial properties for the synergistic improvement of oral wound healing

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-8612

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DC Field	Value	Language
dc.contributor.author	Müller-Heupt, Lena Katharina	-
dc.contributor.author	Wiesmann, Nadine	-
dc.contributor.author	Schröder, Sofia	-
dc.contributor.author	Korkmaz, Yüksel	-
dc.contributor.author	Vierengel, Nina	-
dc.contributor.author	Groß, Jonathan	-
dc.contributor.author	Dahm, Rolf	-
dc.contributor.author	Deschner, James	-
dc.contributor.author	Opatz, Till	-
dc.contributor.author	Brieger, Juergen	-
dc.contributor.author	Al-Nawas, Bilal	-
dc.contributor.author	Kämmerer, Peer W.	-
dc.date.accessioned	2023-01-24T08:08:34Z	-
dc.date.available	2023-01-24T08:08:34Z	-
dc.date.issued	2022	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/8628	-
dc.description.abstract	Various local and systemic factors compromise oral wound healing and may lead to wound dehiscence, inflammation, or ulcers. Currently, there is a lack of topical therapeutical options. Thus, this study aimed to investigate the effect of Aloe vera (AV) and Rheum palmatum root (RPR) on oral wound healing capacity in vitro. The effect of AV and RPR on human primary fibroblast viability and migration was studied by measuring metabolic activity and gap closure in a scratch assay. Furthermore, cell cycle distribution and cytoskeletal features were analyzed. Antimicrobial activity against the oral pathogen Porphyromonas gingivalis was evaluated by broth microdilution assay. AV and RPR increased fibroblast migration after single agent treatment. Synergistic effects of the plant extract combination were observed regarding cellular migration which were confirmed by calculation of the phenomenological combination index (pCI), whereas the cell cycle distribution was not influenced. Furthermore, the combination of AV and RPR showed synergistic antibacterial effects as determined by the fractional inhibitory concentration index. This study demonstrated that the combination of AV and RPR can promote the migration of human primary fibroblasts in vitro and exert antimicrobial efficacy against P. gingivalis, suggesting these compounds for the topical treatment of wound healing disorders.	en_GB
dc.description.sponsorship	Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 491381577	de
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Extracts of Rheum palmatum and Aloe vera show beneficial properties for the synergistic improvement of oral wound healing	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-8612	-
jgu.type.contenttype	Scientific article	de
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Pharmaceutics	de
jgu.journal.volume	14	de
jgu.journal.issue	10	de
jgu.pages.alternative	2060	de
jgu.publisher.year	2022	-
jgu.publisher.name	MDPI	de
jgu.publisher.place	Basel	de
jgu.publisher.issn	1999-4923	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
jgu.publisher.doi	10.3390/pharmaceutics14102060	de
jgu.organisation.ror	https://ror.org/023b0x485	-
jgu.subject.dfg	Lebenswissenschaften	de
Appears in collections:	DFG-491381577-G

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