Gutenberg Open Science: N-cadherin distinguishes intrahepatic cholangiocarcinoma from liver metastases of ductal adenocarcinoma of the pancreas

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-8570

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DC Field	Value	Language
dc.contributor.author	Gerber, Tiemo S.	-
dc.contributor.author	Goeppert, Benjamin	-
dc.contributor.author	Hausen, Anne	-
dc.contributor.author	Witzel, Hagen R.	-
dc.contributor.author	Bartsch, Fabian	-
dc.contributor.author	Schindeldecker, Mario	-
dc.contributor.author	Gröger, Lisa-Katharina	-
dc.contributor.author	Ridder, Dirk A.	-
dc.contributor.author	Cahyadi, Oscar	-
dc.contributor.author	Esposito, Irene	-
dc.contributor.author	Gaida, Matthias M.	-
dc.contributor.author	Schirmacher, Peter	-
dc.contributor.author	Galle, Peter R.	-
dc.contributor.author	Lang, Hauke	-
dc.contributor.author	Roth, Wilfried	-
dc.contributor.author	Straub, Beate K.	-
dc.date.accessioned	2023-01-13T11:00:09Z	-
dc.date.available	2023-01-13T11:00:09Z	-
dc.date.issued	2022	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/8586	-
dc.description.abstract	The differential diagnosis of primary liver cancer versus liver metastases of an extrahepatic primary tumor may be challenging, especially in carcinoma of the pancreatobiliary phenotype, as in intrahepatic cholangiocarcinoma or metastases of ductal adenocarcinoma of the pancreas. Nevertheless, the distinction is of fundamental importance for therapy planning. In the frame of this study, we focus on the differential expression and localization of the cell–cell contact-proteins E-cadherin and N-cadherin, markers for cell differentiation in normal epithelia of the pancreaticobiliary tract as well as in derived tumors, and demonstrate that N-cadherin positivity distinguishes intrahepatic cholangiocarcinoma from liver metastases of ductal adenocarcinoma of the pancreas. We propose that N-cadherin-positivity together with other biliary markers may be used for this important histopathological differential diagnosis and may thus improve the accuracy of cholangiocarcinoma diagnosis.	en_GB
dc.description.sponsorship	Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 491381577	de
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	N-cadherin distinguishes intrahepatic cholangiocarcinoma from liver metastases of ductal adenocarcinoma of the pancreas	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-8570	-
jgu.type.contenttype	Scientific article	de
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Cancers	de
jgu.journal.volume	14	de
jgu.journal.issue	13	de
jgu.pages.alternative	3091	de
jgu.publisher.year	2022	-
jgu.publisher.name	MDPI	de
jgu.publisher.place	Basel	de
jgu.publisher.issn	2072-6694	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
jgu.publisher.doi	10.3390/cancers14133091	de
jgu.organisation.ror	https://ror.org/023b0x485	-
jgu.subject.dfg	Lebenswissenschaften	de
Appears in collections:	DFG-491381577-G

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