Authors:	Gerber, Tiemo S. Goeppert, Benjamin Hausen, Anne Witzel, Hagen R. Bartsch, Fabian Schindeldecker, Mario Gröger, Lisa-Katharina Ridder, Dirk A. Cahyadi, Oscar Esposito, Irene Gaida, Matthias M. Schirmacher, Peter Galle, Peter R. Lang, Hauke Roth, Wilfried Straub, Beate K.
Title:	N-cadherin distinguishes intrahepatic cholangiocarcinoma from liver metastases of ductal adenocarcinoma of the pancreas
Online publication date:	13-Jan-2023
Year of first publication:	2022
Language:	english
Abstract:	The differential diagnosis of primary liver cancer versus liver metastases of an extrahepatic primary tumor may be challenging, especially in carcinoma of the pancreatobiliary phenotype, as in intrahepatic cholangiocarcinoma or metastases of ductal adenocarcinoma of the pancreas. Nevertheless, the distinction is of fundamental importance for therapy planning. In the frame of this study, we focus on the differential expression and localization of the cell–cell contact-proteins E-cadherin and N-cadherin, markers for cell differentiation in normal epithelia of the pancreaticobiliary tract as well as in derived tumors, and demonstrate that N-cadherin positivity distinguishes intrahepatic cholangiocarcinoma from liver metastases of ductal adenocarcinoma of the pancreas. We propose that N-cadherin-positivity together with other biliary markers may be used for this important histopathological differential diagnosis and may thus improve the accuracy of cholangiocarcinoma diagnosis.
DDC:	610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-8570
Version:	Published version
Publication type:	Zeitschriftenaufsatz
Document type specification:	Scientific article
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/4.0/
Journal:	Cancers 14 13
Pages or article number:	3091
Publisher:	MDPI
Publisher place:	Basel
Issue date:	2022
ISSN:	2072-6694
Publisher DOI:	10.3390/cancers14133091
Appears in collections:	DFG-491381577-G