Autoren:	Gerber, Tiemo S. Goeppert, Benjamin Hausen, Anne Witzel, Hagen R. Bartsch, Fabian Schindeldecker, Mario Gröger, Lisa-Katharina Ridder, Dirk A. Cahyadi, Oscar Esposito, Irene Gaida, Matthias M. Schirmacher, Peter Galle, Peter R. Lang, Hauke Roth, Wilfried Straub, Beate K.
Titel:	N-cadherin distinguishes intrahepatic cholangiocarcinoma from liver metastases of ductal adenocarcinoma of the pancreas
Online-Publikationsdatum:	13-Jan-2023
Erscheinungsdatum:	2022
Sprache des Dokuments:	Englisch
Zusammenfassung/Abstract:	The differential diagnosis of primary liver cancer versus liver metastases of an extrahepatic primary tumor may be challenging, especially in carcinoma of the pancreatobiliary phenotype, as in intrahepatic cholangiocarcinoma or metastases of ductal adenocarcinoma of the pancreas. Nevertheless, the distinction is of fundamental importance for therapy planning. In the frame of this study, we focus on the differential expression and localization of the cell–cell contact-proteins E-cadherin and N-cadherin, markers for cell differentiation in normal epithelia of the pancreaticobiliary tract as well as in derived tumors, and demonstrate that N-cadherin positivity distinguishes intrahepatic cholangiocarcinoma from liver metastases of ductal adenocarcinoma of the pancreas. We propose that N-cadherin-positivity together with other biliary markers may be used for this important histopathological differential diagnosis and may thus improve the accuracy of cholangiocarcinoma diagnosis.
DDC-Sachgruppe:	610 Medizin 610 Medical sciences
Veröffentlichende Institution:	Johannes Gutenberg-Universität Mainz
Organisationseinheit:	FB 04 Medizin
Veröffentlichungsort:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-8570
Version:	Published version
Publikationstyp:	Zeitschriftenaufsatz
Weitere Angaben zur Dokumentart:	Scientific article
Nutzungsrechte:	CC BY
Informationen zu den Nutzungsrechten:	https://creativecommons.org/licenses/by/4.0/
Zeitschrift:	Cancers 14 13
Seitenzahl oder Artikelnummer:	3091
Verlag:	MDPI
Verlagsort:	Basel
Erscheinungsdatum:	2022
ISSN:	2072-6694
DOI der Originalveröffentlichung:	10.3390/cancers14133091
Enthalten in den Sammlungen:	DFG-491381577-G