Authors:	Stengelin, Elena Thiele, Julian Seiffert, Sebastian
Title:	Multiparametric material functionality of microtissue-based in vitro models as alternatives to animal testing
Online publication date:	30-Nov-2022
Year of first publication:	2022
Language:	english
Abstract:	With the definition of the 3R principle by Russel and Burch in 1959, the search for an adequate substitute for animal testing has become one of the most important tasks and challenges of this time, not only from an ethical, but also from a scientific, economic, and legal point of view. Microtissue-based in vitro model systems offer a valuable approach to address this issue by accounting for the complexity of natural tissues in a simplified manner. To increase the functionality of these model systems and thus make their use as a substitute for animal testing more likely in the future, the fundamentals need to be continuously improved. Corresponding requirements exist in the development of multifunctional, hydrogel-based materials, whose properties are considered in this review under the aspects of processability, adaptivity, biocompatibility, and stability/degradability.
DDC:	540 Chemie 540 Chemistry and allied sciences 610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 09 Chemie, Pharmazie u. Geowissensch.
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-8445
Version:	Published version
Publication type:	Zeitschriftenaufsatz
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/4.0/
Journal:	Advanced science 9 10
Pages or article number:	2105319
Publisher:	Wiley-VCH
Publisher place:	Weinheim
Issue date:	2022
ISSN:	2198-3844
Publisher DOI:	10.1002/advs.202105319
Appears in collections:	JGU-Publikationen