Please use this identifier to cite or link to this item:
Authors: Blanchard, John W.
Ripka, Barbara
Suslick, Benjamin A.
Gelevski, Dario
Wu, Teng
Münnemann, Kerstin
Barskiy, Danila A.
Budker, Dmitry
Title: Towards large-scale steady-state enhanced nuclear magnetization with in situ detection
Online publication date: 14-Nov-2022
Year of first publication: 2021
Language: english
Abstract: Signal amplification by reversible exchange (SABRE) boosts NMR signals of various nuclei enabling new applications spanning from magnetic resonance imaging to analytical chemistry and fundamental physics. SABRE is especially well positioned for continuous generation of enhanced magnetization on a large scale; however, several challenges need to be addressed for accomplishing this goal. Specifically, SABRE requires (i) a specialized catalyst capable of reversible H2 activation and (ii) physical transfer of the sample from the point of magnetization generation to the point of detection (e.g., a high-field or a benchtop nuclear magnetic resonance [NMR] spectrometer). Moreover, (iii) continuous parahydrogen bubbling accelerates solvent (e.g., methanol) evaporation, thereby limiting the experimental window to tens of minutes per sample. In this work, we demonstrate a strategy to rapidly generate the best-to-date precatalyst (a compound that is chemically modified in the course of the reaction to yield the catalyst) for SABRE, [Ir(IMes)(COD)Cl] (IMes = 1,3-bis-[2,4,6-trimethylphenyl]-imidazol-2-ylidene; COD = cyclooctadiene) via a highly accessible synthesis. Second, we measure hyperpolarized samples using a home-built zero-field NMR spectrometer and study the field dependence of hyperpolarization directly in the detection apparatus, eliminating the need to physically move the sample during the experiment. Finally, we prolong the measurement time and reduce evaporation by presaturating parahydrogen with the solvent vapor before bubbling into the sample. These advancements extend opportunities for exploring SABRE hyperpolarization by researchers from various fields and pave the way to producing large quantities of hyperpolarized material for long-lasting detection of SABRE-derived nuclear magnetization.
DDC: 530 Physik
530 Physics
540 Chemie
540 Chemistry and allied sciences
Institution: Johannes Gutenberg-Universität Mainz
Department: FB 08 Physik, Mathematik u. Informatik
Helmholtz Institut Mainz
Place: Mainz
Version: Published version
Publication type: Zeitschriftenaufsatz
License: CC BY-NC
Information on rights of use:
Journal: Magnetic resonance in chemistry
Pages or article number: 1208
Publisher: Wiley
Publisher place: Chichester
Issue date: 2021
ISSN: 1097-458X
Publisher DOI: 10.1002/mrc.5161
Appears in collections:JGU-Publikationen

Files in This Item:
  File Description SizeFormat
towards_largescale_steadystat-20221017155708364.pdf4.46 MBAdobe PDFView/Open