Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-8025
Authors: | Stergiou, Natascha Urschbach, Moritz Gabba, Adele Schmitt, Edgar Kunz, Horst Besenius, Pol |
Title: | The development of vaccines from synthetic tumor-associated mucin glycopeptides and their glycosylation-dependent immune response |
Online publication date: | 24-Oct-2022 |
Year of first publication: | 2021 |
Language: | english |
Abstract: | Tumor-associated carbohydrate antigens are overexpressed as altered-self in most common epithelial cancers. Their glycosylation patterns differ from those of healthy cells, functioning as an ID for cancer cells. Scientists have been developing anti-cancer vaccines based on mucin glycopeptides, yet the interplay of delivery system, adjuvant and tumor associated MUC epitopes in the induced immune response is not well understood. The current state of the art suggests that the identity, abundancy and location of the glycans on the MUC backbone are all key parameters in the cellular and humoral response. This review shares lessons learned by us in over two decades of research in glycopeptide vaccines. By bridging synthetic chemistry and immunology, we discuss efforts in designing synthetic MUC1/4/16 vaccines and focus on the role of glycosylation patterns. We provide a brief introduction into the mechanisms of the immune system and aim to promote the development of cancer subunit vaccines. |
DDC: | 540 Chemie 540 Chemistry and allied sciences |
Institution: | Johannes Gutenberg-Universität Mainz |
Department: | FB 09 Chemie, Pharmazie u. Geowissensch. |
Place: | Mainz |
ROR: | https://ror.org/023b0x485 |
DOI: | http://doi.org/10.25358/openscience-8025 |
Version: | Published version |
Publication type: | Zeitschriftenaufsatz |
License: | CC BY |
Information on rights of use: | https://creativecommons.org/licenses/by/4.0/ |
Journal: | The chemical record 21 11 |
Pages or article number: | 3313 3331 |
Publisher: | Wiley |
Publisher place: | New York, NY |
Issue date: | 2021 |
ISSN: | 1528-0691 |
Publisher DOI: | 10.1002/tcr.202100182 |
Appears in collections: | JGU-Publikationen |
Files in This Item:
File | Description | Size | Format | ||
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the_development_of_vaccines_f-20221014155758630.pdf | 1.29 MB | Adobe PDF | View/Open |