Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-8025
Authors: Stergiou, Natascha
Urschbach, Moritz
Gabba, Adele
Schmitt, Edgar
Kunz, Horst
Besenius, Pol
Title: The development of vaccines from synthetic tumor-associated mucin glycopeptides and their glycosylation-dependent immune response
Online publication date: 24-Oct-2022
Year of first publication: 2021
Language: english
Abstract: Tumor-associated carbohydrate antigens are overexpressed as altered-self in most common epithelial cancers. Their glycosylation patterns differ from those of healthy cells, functioning as an ID for cancer cells. Scientists have been developing anti-cancer vaccines based on mucin glycopeptides, yet the interplay of delivery system, adjuvant and tumor associated MUC epitopes in the induced immune response is not well understood. The current state of the art suggests that the identity, abundancy and location of the glycans on the MUC backbone are all key parameters in the cellular and humoral response. This review shares lessons learned by us in over two decades of research in glycopeptide vaccines. By bridging synthetic chemistry and immunology, we discuss efforts in designing synthetic MUC1/4/16 vaccines and focus on the role of glycosylation patterns. We provide a brief introduction into the mechanisms of the immune system and aim to promote the development of cancer subunit vaccines.
DDC: 540 Chemie
540 Chemistry and allied sciences
Institution: Johannes Gutenberg-Universität Mainz
Department: FB 09 Chemie, Pharmazie u. Geowissensch.
Place: Mainz
ROR: https://ror.org/023b0x485
DOI: http://doi.org/10.25358/openscience-8025
Version: Published version
Publication type: Zeitschriftenaufsatz
License: CC BY
Information on rights of use: https://creativecommons.org/licenses/by/4.0/
Journal: The chemical record
21
11
Pages or article number: 3313
3331
Publisher: Wiley
Publisher place: New York, NY
Issue date: 2021
ISSN: 1528-0691
Publisher DOI: 10.1002/tcr.202100182
Appears in collections:JGU-Publikationen

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