Authors:	Keller, Stefanie Schmidt, Mirko HH
Title:	EGFR and EGFRvIII promote angiogenesis and cell invasion in glioblastoma : combination therapies for an effective treatment
Online publication date:	7-Oct-2022
Year of first publication:	2017
Language:	english
Abstract:	Epidermal growth factor receptor (EGFR) and the mutant EGFRvIII are major focal points in current concepts of targeted cancer therapy for glioblastoma multiforme (gbm), the most malignant primary brain tumor. the receptors participate in the key processes of tumor cell invasion and tumor-related angiogenesis and their upregulation correlates with the poor prognosis of glioma patients. glioma cell invasion and increased angiogenesis share mechanisms of the degradation of the extracellular matrix (ecm) through upregulation of ecm-degrading proteases as well as the activation of aberrant signaling pathways. this review describes the role of egfr and egfrviii in those mechanisms which might offer new combined therapeutic approaches targeting egfr or egfrviii together with drug treatments against proteases of the ecm or downstream signaling to increase the inhibitory effects of mono-therapies.
DDC:	610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-7902
Version:	Published version
Publication type:	Zeitschriftenaufsatz
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/4.0/
Journal:	International journal of molecular sciences 18 6
Pages or article number:	Art. 1295
Publisher:	Molecular Diversity Preservation International
Publisher place:	Basel
Issue date:	2017
ISSN:	1422-0067 1661-6596
Publisher URL:	http://dx.doi.org/10.3390/ijms18061295
Publisher DOI:	10.3390/ijms18061295
Appears in collections:	DFG-OA-Publizieren (2012 - 2017)