EGFR and EGFRvIII promote angiogenesis and cell invasion in glioblastoma : combination therapies for an effective treatment

Keller, Stefanie; Schmidt, Mirko HH

EGFR and EGFRvIII promote angiogenesis and cell invasion in glioblastoma : combination therapies for an effective treatment

dc.contributor.author	Keller, Stefanie
dc.contributor.author	Schmidt, Mirko HH
dc.date.accessioned	2022-10-07T09:18:43Z
dc.date.available	2022-10-07T09:18:43Z
dc.date.issued	2017
dc.description.abstract	Epidermal growth factor receptor (EGFR) and the mutant EGFRvIII are major focal points in current concepts of targeted cancer therapy for glioblastoma multiforme (gbm), the most malignant primary brain tumor. the receptors participate in the key processes of tumor cell invasion and tumor-related angiogenesis and their upregulation correlates with the poor prognosis of glioma patients. glioma cell invasion and increased angiogenesis share mechanisms of the degradation of the extracellular matrix (ecm) through upregulation of ecm-degrading proteases as well as the activation of aberrant signaling pathways. this review describes the role of egfr and egfrviii in those mechanisms which might offer new combined therapeutic approaches targeting egfr or egfrviii together with drug treatments against proteases of the ecm or downstream signaling to increase the inhibitory effects of mono-therapies.	en_GB
dc.description.sponsorship	DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin	de
dc.identifier.doi	http://doi.org/10.25358/openscience-7902
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/7917
dc.language.iso	eng	de
dc.rights	CC-BY-4.0	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	EGFR and EGFRvIII promote angiogenesis and cell invasion in glioblastoma : combination therapies for an effective treatment	en_GB
dc.type	Zeitschriftenaufsatz	de
jgu.journal.issue	6	de
jgu.journal.title	International journal of molecular sciences	de
jgu.journal.volume	18	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.name	Johannes Gutenberg-Universität Mainz
jgu.organisation.number	2700
jgu.organisation.place	Mainz
jgu.organisation.ror	https://ror.org/023b0x485
jgu.pages.alternative	Art. 1295	de
jgu.publisher.doi	10.3390/ijms18061295	de
jgu.publisher.issn	1422-0067	de
jgu.publisher.issn	1661-6596	de
jgu.publisher.name	Molecular Diversity Preservation International	de
jgu.publisher.place	Basel	de
jgu.publisher.uri	http://dx.doi.org/10.3390/ijms18061295	de
jgu.publisher.year	2017
jgu.rights.accessrights	openAccess
jgu.subject.ddccode	610	de
jgu.type.dinitype	Article	en_GB
jgu.type.resource	Text	de
jgu.type.version	Published version	de
opus.affiliated	Schmidt, Mirko HH
opus.date.modified	2018-03-23T11:17:38Z
opus.identifier.opusid	57999
opus.institute.number	0459
opus.metadataonly	false
opus.organisation.string	FB 04: Medizin: Institut für Mikroskopische Anatomie und Neurobiologie	de_DE
opus.subject.dfgcode	00-000
opus.type.contenttype	Keine	de_DE
opus.type.contenttype	None	en_EN

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