Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-7806
Authors: | Klebow, Sabrina Hahn, Matthias Nikoalev, Alexei Wunderlich, F. Thomas Hövelmeyer, Nadine Karbach, Susanne Waisman, Ari |
Title: | IL-6 signaling in myelomonocytic cells is not crucial for the development of IMQ-induced psoriasis |
Online publication date: | 4-Oct-2022 |
Year of first publication: | 2016 |
Language: | english |
Abstract: | Psoriasis is an autoimmune skin disease that is associated with aberrant activity of immune cells and keratinocytes. In mice, topical application of TLR7/8 agonist IMQ leads to a skin disorder resembling human psoriasis. Recently, it was shown that the IL-23/ IL-17 axis plays a deciding role in the pathogenesis of human psoriasis, as well as in the mouse model of IMQ-induced psoriasis-like skin disease. A consequence of IL-17A production in the skin includes increased expression and production of IL-6, resulting in the recruitment of neutrophils and other myelomonocytic cells to the site of inflammation. To further investigate and characterize the exact role of IL-6 signaling in myelomonocytic cells during experimental psoriasis, we generated mice lacking the IL-6 receptor alpha specifically in myelomonocytic cells (IL-6RαΔmyel). Surprisingly, disease susceptibility of these mice was not affected in this model. Our study shows that classical IL-6 signaling in myelomonocytic cells does not play an essential role for disease development of IMQ-induced psoriasis-like skin disease. |
DDC: | 610 Medizin 610 Medical sciences |
Institution: | Johannes Gutenberg-Universität Mainz |
Department: | FB 04 Medizin |
Place: | Mainz |
ROR: | https://ror.org/023b0x485 |
DOI: | http://doi.org/10.25358/openscience-7806 |
Version: | Published version |
Publication type: | Zeitschriftenaufsatz |
License: | CC BY |
Information on rights of use: | https://creativecommons.org/licenses/by/4.0/ |
Journal: | PLoS one 11 3 |
Pages or article number: | e0151913 |
Publisher: | PLoS |
Publisher place: | Lawrence, Kan. |
Issue date: | 2016 |
ISSN: | 1932-6203 |
Publisher URL: | http://dx.doi.org/10.1371/journal.pone.0151913 |
Publisher DOI: | 10.1371/journal.pone.0151913 |
Appears in collections: | DFG-OA-Publizieren (2012 - 2017) |
Files in This Item:
File | Description | Size | Format | ||
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il6_signaling_in_myelomonocyt-20220913235916796.pdf | 1.95 MB | Adobe PDF | View/Open |