Gutenberg Open Science: IL-6 signaling in myelomonocytic cells is not crucial for the development of IMQ-induced psoriasis

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7806

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DC Field	Value	Language
dc.contributor.author	Klebow, Sabrina	-
dc.contributor.author	Hahn, Matthias	-
dc.contributor.author	Nikoalev, Alexei	-
dc.contributor.author	Wunderlich, F. Thomas	-
dc.contributor.author	Hövelmeyer, Nadine	-
dc.contributor.author	Karbach, Susanne	-
dc.contributor.author	Waisman, Ari	-
dc.date.accessioned	2022-10-04T09:27:39Z	-
dc.date.available	2022-10-04T09:27:39Z	-
dc.date.issued	2016
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/7821	-
dc.description.abstract	Psoriasis is an autoimmune skin disease that is associated with aberrant activity of immune cells and keratinocytes. In mice, topical application of TLR7/8 agonist IMQ leads to a skin disorder resembling human psoriasis. Recently, it was shown that the IL-23/ IL-17 axis plays a deciding role in the pathogenesis of human psoriasis, as well as in the mouse model of IMQ-induced psoriasis-like skin disease. A consequence of IL-17A production in the skin includes increased expression and production of IL-6, resulting in the recruitment of neutrophils and other myelomonocytic cells to the site of inflammation. To further investigate and characterize the exact role of IL-6 signaling in myelomonocytic cells during experimental psoriasis, we generated mice lacking the IL-6 receptor alpha specifically in myelomonocytic cells (IL-6RαΔmyel). Surprisingly, disease susceptibility of these mice was not affected in this model. Our study shows that classical IL-6 signaling in myelomonocytic cells does not play an essential role for disease development of IMQ-induced psoriasis-like skin disease.	en_GB
dc.description.sponsorship	DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin	de
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	IL-6 signaling in myelomonocytic cells is not crucial for the development of IMQ-induced psoriasis	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-7806	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	PLoS one	de
jgu.journal.volume	11	de
jgu.journal.issue	3	de
jgu.pages.alternative	e0151913	de
jgu.publisher.year	2016	-
jgu.publisher.name	PLoS	de
jgu.publisher.place	Lawrence, Kan.	de
jgu.publisher.uri	http://dx.doi.org/10.1371/journal.pone.0151913	de
jgu.publisher.issn	1932-6203	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
opus.date.modified	2018-08-23T08:22:58Z
opus.subject.dfgcode	00-000
opus.organisation.string	FB 04: Medizin: II. Medizinische Klinik und Poliklinik	de_DE
opus.organisation.string	FB 04: Medizin: Institut für Molekulare Medizin	de_DE
opus.identifier.opusid	56325
opus.institute.number	0426
opus.institute.number	0458
opus.metadataonly	false
opus.type.contenttype	Keine	de_DE
opus.type.contenttype	None	en_EN
opus.affiliated	Karbach, Susanne
opus.affiliated	Waisman, Ari
jgu.publisher.doi	10.1371/journal.pone.0151913	de
jgu.organisation.ror	https://ror.org/023b0x485	-
Appears in collections:	DFG-OA-Publizieren (2012 - 2017)

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