Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-7720
Authors: | Helmstädter, Johanna Keppeler, Karin Küster, Leonie Münzel, Thomas Daiber, Andreas Steven, Sebastian |
Title: | Glucagon-like peptide-1 (GLP-1) receptor agonists and their cardiovascular benefits : the role of the GLP-1 receptor |
Online publication date: | 12-Sep-2022 |
Year of first publication: | 2022 |
Language: | english |
Abstract: | Cardiovascular outcome trials revealed cardiovascular benefits for type 2 diabetes mellitus patients when treated with long-acting glucagon-like peptide-1 (GLP-1) receptor agonists. In the last decade, major advances were made characterising the physiological effects of GLP-1 and its action on numerous targets including brain, liver, kidney, heart and blood vessels. However, the effects of GLP-1 and receptor agonists, and the GLP-1 receptor on the cardiovascular system have not been fully elucidated. We compare results from cardiovascular outcome trials of GLP-1 receptor agonists and review pleiotropic clinical and preclinical data concerning cardiovascular protection beyond glycaemic control. We address current knowledge on GLP-1 and receptor agonist actions on the heart, vasculature, inflammatory cells and platelets, and discuss evidence for GLP-1 receptor-dependent versus independent effects secondary of GLP-1 metabolites. We conclude that the favourable cardiovascular profile of GLP-1 receptor agonists might expand their therapeutic use for treating cardiovascular disease even in non-diabetic populations. |
DDC: | 610 Medizin 610 Medical sciences |
Institution: | Johannes Gutenberg-Universität Mainz |
Department: | FB 04 Medizin |
Place: | Mainz |
ROR: | https://ror.org/023b0x485 |
DOI: | http://doi.org/10.25358/openscience-7720 |
Version: | Published version |
Publication type: | Zeitschriftenaufsatz |
License: | CC BY-NC-ND |
Information on rights of use: | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
Journal: | British journal of pharmacology 179 4 |
Pages or article number: | 659 676 |
Publisher: | Wiley |
Publisher place: | Malden, MA |
Issue date: | 2022 |
ISSN: | 1476-5381 |
Publisher DOI: | 10.1111/bph.15462 |
Appears in collections: | JGU-Publikationen |
Files in This Item:
File | Description | Size | Format | ||
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glucagonlike_peptide1_glp1_re-20220905115559788.pdf | 2.7 MB | Adobe PDF | View/Open |