Autoren:	Baeken, Marius W. Behl, Christian
Titel:	On the origin of BAG(3) and its consequences for an expansion of BAG3's role in protein homeostasis
Online-Publikationsdatum:	12-Sep-2022
Erscheinungsdatum:	2022
Sprache des Dokuments:	Englisch
Zusammenfassung/Abstract:	The B-cell CLL 2-associated athanogene (BAG) protein family in general and BAG3, in particular, are pivotal elements of cellular protein homeostasis, with BAG3 playing a major role in macroautophagy. In particular, in the contexts of senescence and degeneration, BAG3 has exhibited an essential role often related to its capabilities to organize and remove aggregated proteins. Exciting studies in different species ranging from human, murine, zebrafish, and plant samples have delivered vital insights into BAG3s' (and other BAG proteins') functions and their regulations. However, so far no studies have addressed neither BAG3's evolution nor its phylogenetic position in the BAG family.
DDC-Sachgruppe:	610 Medizin 610 Medical sciences
Veröffentlichende Institution:	Johannes Gutenberg-Universität Mainz
Organisationseinheit:	FB 04 Medizin
Veröffentlichungsort:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-7718
Version:	Published version
Publikationstyp:	Zeitschriftenaufsatz
Nutzungsrechte:	CC BY-NC
Informationen zu den Nutzungsrechten:	https://creativecommons.org/licenses/by-nc/4.0/
Zeitschrift:	Journal of cellular biochemistry 123 1
Seitenzahl oder Artikelnummer:	102 114 Special Issue: The co-chaperone BAG3: Orchestrator of the cellular task force in response to stress
Verlag:	Wiley-Liss
Verlagsort:	New York, NY
Erscheinungsdatum:	2022
ISSN:	1097-4644
DOI der Originalveröffentlichung:	10.1002/jcb.29925
Enthalten in den Sammlungen:	JGU-Publikationen