Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7707
Authors: Engelhardt, Jakob von
Title: Role of AMPA receptor desensitization in short term depression : lessons from retinogeniculate synapses
Online publication date: 12-Sep-2022
Year of first publication: 2022
Language: english
Abstract: Repetitive synapse activity induces various forms of short-term plasticity. The role of presynaptic mechanisms such as residual Ca2+ and vesicle depletion in short-term facilitation and short-term depression is well established. On the other hand, the contribution of postsynaptic mechanisms such as receptor desensitization and saturation to short-term plasticity is less well known and often ignored. In this review, I will describe short-term plasticity in retinogeniculate synapses of relay neurons of the dorsal lateral geniculate nucleus (dLGN) to exemplify the synaptic properties that facilitate the contribution of AMPA receptor desensitization to short-term plasticity. These include high vesicle release probability, glutamate spillover and, importantly, slow recovery from desensitization of AMPA receptors. The latter is strongly regulated by the interaction of AMPA receptors with auxiliary proteins such as CKAMP44. Finally, I discuss the relevance of short-term plasticity in retinogeniculate synapses for the processing of visual information by LGN relay neurons.
DDC: 610 Medizin
610 Medical sciences
Institution: Johannes Gutenberg-Universität Mainz
Department: FB 04 Medizin
Place: Mainz
ROR: https://ror.org/023b0x485
DOI: http://doi.org/10.25358/openscience-7707
Version: Published version
Publication type: Zeitschriftenaufsatz
License: CC BY
Information on rights of use: https://creativecommons.org/licenses/by/4.0/
Journal: The journal of physiology
600
2
Pages or article number: 201
215
Publisher: Wiley-Blackwell
Publisher place: Hoboken, NJ
Issue date: 2022
ISSN: 1469-7793
Publisher DOI: 10.1113/JP280878
Appears in collections:JGU-Publikationen

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