Gutenberg Open Science: Criss-crossing autism spectrum disorder and adult neurogenesis

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7693

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DC Field	Value	Language
dc.contributor.author	Bicker, Frank	-
dc.contributor.author	Nardi, Leonardo	-
dc.contributor.author	Maier, Jannik	-
dc.contributor.author	Vasic, Verica	-
dc.contributor.author	Schmeisser, Michael J.	-
dc.date.accessioned	2022-09-07T09:22:32Z	-
dc.date.available	2022-09-07T09:22:32Z	-
dc.date.issued	2021	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/7708	-
dc.description.abstract	Autism spectrum disorder (ASD) comprises a group of multifactorial neurodevelopmental disorders primarily characterized by deficits in social interaction and repetitive behavior. Although the onset is typically in early childhood, ASD poses a lifelong challenge for both patients and caretakers. Adult neurogenesis (AN) is the process by which new functional neurons are created from neural stem cells existing in the post-natal brain. The entire event is based on a sequence of cellular processes, such as proliferation, specification of cell fate, maturation, and ultimately, synaptic integration into the existing neural circuits. Hence, AN is implicated in structural and functional brain plasticity throughout life. Accumulating evidence shows that impaired AN may underlie some of the abnormal behavioral phenotypes seen in ASD. In this review, we approach the interconnections between the molecular pathways related to AN and ASD. We also discuss existing therapeutic approaches targeting such pathways both in preclinical and clinical studies. A deeper understanding of how ASD and AN reciprocally affect one another could reveal important converging pathways leading to the emergence of psychiatric disorders.	en_GB
dc.language.iso	eng	de
dc.rights	CC BY-NC-ND	*
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Criss-crossing autism spectrum disorder and adult neurogenesis	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-7693	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Journal of neurochemistry	de
jgu.journal.volume	159	de
jgu.journal.issue	3	de
jgu.pages.start	452	de
jgu.pages.end	478	de
jgu.publisher.year	2021	-
jgu.publisher.name	Wiley-Blackwell	de
jgu.publisher.place	Oxford	de
jgu.publisher.issn	1471-4159	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
jgu.publisher.doi	10.1111/jnc.15501	de
jgu.organisation.ror	https://ror.org/023b0x485	-
Appears in collections:	JGU-Publikationen

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